Method of gene transfer using retrotransposons

Details Method of gene transfer using retrotransposons Method of gene transfer using retrotransposons

1992-10-29

1994-10-11

Hill, Jr., Robert J.

Chemistry: molecular biology and microbiology

Treatment of micro-organisms or enzymes with electrical or...

Modification of viruses

435 691, 4351721, 4351722, 4352351, 4353201, 4352402, C12N 1500, C12N 500, C12N 700

Patent

active

053546741

ABSTRACT:
A process for the transfer and/or expression of any gene into cells, organisms or species is disclosed. The process involves isolating the gene, introducing the gene into a vector comprised of at least one retrotransposon genetic element to provide a hybrid gene. The hybrid gene is introduced into a donor cell capable of packaging and transmitting the retrotransposon to other cells, organisms or species. The hybrid gene is transferred to a recipient cell wherein the hybrid gene replicates by reverse transcription and is inserted into the recipient cell's genome. The gene is preferably expressed as RNA and/or protein, giving the phenotype of the gene.

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