Prosthesis (i.e. – artificial body members) – parts thereof – or ai – Implantable prosthesis – Bone
Patent
1995-11-13
1997-08-26
Clarke, Robert A. H.
Prosthesis (i.e., artificial body members), parts thereof, or ai
Implantable prosthesis
Bone
606 74, 128898, 623 11, A61F 228
Patent
active
056602251
ABSTRACT:
The invention and the corresponding method of fracture stabilization provided is a malleable medication-containing device that is capable of both stabilizing fracture fragments and delivering medicines directly to fracture fragments when wrapped around or affixed to fractured tissues. This invention is designed to be used in conjunction with rigid fixation devices when rigid fixation is required of the major fragments. The novel device is comprised of two layers affixed to each other by chemical or mechanical means: a flexible, minimally-porous biologically-compatible fabric and a flexible biologically-compatible microporous polymer into which desired medications have been embedded. The preferred method of employment is to wrap the device around a fracture with the medication side in; and tighten it until the desired tension is achieved, thereby holding native fracture fragments in register. The medications imbedded in the microporous component subsequently diffuse in timed-release fashion from the microporous polymer directly into the fracture site. When the device is wrapped around or affixed to the fracture, the diffusion of embedded medicines is unidirectional. The minimally-porous surface, being relatively impermeable to macromolecules, directs the released medicine into the fracture site and away from surrounding tissues. The minimally-porous material can be made of any suitable fabric or polymer sheet such that, when affixed to the microporous layer, it is minimally permeable to macromolecules and can be manipulated by the surgeon at the time of use. Similarly, the microporous material can be of any suitable polymer such that, when affixed to the minimally-porous component, it can be made to contain and release into solution medications that can diffuse to the site of injury. The entire invention can, depending on the materials of which it is composed, either be removed surgically at a later time, or resorb in situ, over the course of weeks to months.
REFERENCES:
patent: 4642120 (1987-02-01), Nevo-Sui
patent: 5002583 (1991-03-01), Pitaru-Sandu
patent: 5084051 (1992-01-01), Tormala et al.
patent: 5443483 (1995-08-01), Kirsch
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