Method of fractionating plasma proteins

Details Method of fractionating plasma proteins Method of fractionating plasma proteins

1990-06-14

1992-08-11

Cashion, Jr., Merrell C.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Separation or purification

530364, 530380, 530381, 530382, 530383, 530384, 530387, 530392, 530393, 530394, 530412, C07K 312, C07K 328

Patent

active

051380340

ABSTRACT:
A method of fractionating plasma protein which comprises treating a plasma protein-containing material in the following sequence of steps, provided that steps (ii) through (v) may be performed in an optional order: (i) freeze-thaw treatment, (ii) treatment at 5 to 10% ethanol concentration, (iii) treatment with an anion exchanger, (iv) affinity chromatography with immobilized lysine, (v) affinity chromatography with immobilized heparin, (vi) treatment at 18 to 30% ethanol concentration, (vii) treatment at 35 to 45% ethanol concentration.

REFERENCES:
patent: 2710293 (1955-06-01), Gerlough
patent: 4025618 (1977-05-01), Garber et al.
Schneider et al., Vox Sang., vol. 31, pp. 141-151 (1976).
Methods of Plasma Protein Fractionation, (Academic Press, 1980), pp. 10-13, 118, 119.
Chemical Abstracts, vol. 94, 1981, p. 365, Abstract No. 99028r.
Chemical Abstracts, vol. 93, 1980, p. 425, Abstract No. 40670v.
Collen et al., Thrombosis Research, vol. 7, pp. 515-529 (1975).
Handin et al., Clin. Res. (U.S.A.), vol. 23, No. 3, p. 275A, (1975), (abstract).

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