Method of fractional quantitative determination of isoenzyme of

Details Method of fractional quantitative determination of isoenzyme of Method of fractional quantitative determination of isoenzyme of

1979-07-03

1981-03-24

Castel, Benoit

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving oxidoreductase

252408, 536 26, C12Q 132

Patent

active

042581311

ABSTRACT:
1,6-Dihydro nicotinamide adenine dinucleotide inhibits both H-type lactic dehydrogenase and M-type lactic dehydrogenase which are isoenzymes of lactic dehydrogenase, but the degree of inhibition thereof against H-type considerably differs from that against M-type. A ratio of H-type lactic dehydrogenase to M-type lactic dehydrogenase in serum can be measured by utilizing the difference of inhibition degree. Therefore we can diagnose the organ with trouble.

REFERENCES:
patent: 4003975 (1977-01-01), Lamprecht
patent: 4006061 (1977-02-01), Weeks et al.
patent: 4080263 (1978-03-01), Bernt et al.
Godfredsen, S. E. & Ottesen, N. "1,6-Dihydro-NAD as an Humidity-Induced Lactate Dehydrogenase Inhibitor in NADH Preparations", Carlsberg Res. Com. vol. 43 (3), pp. 171-175, (1978).
Howell B. F. et al.; "Detection of Inhibitors in Reduced Nicotinamide Adenine Dinucleotide by Kinetic Methods", Clin. Chem., vol. 22, No. 10; pp. 1648-1654, (1976).
Biellmann J. F. et al., "Structure of Lactate Dehydrogenase Inhibitor Generated from Coenzyme"; Biochemistry, vol. 18, No. 7, pp. 1212-1216, (1979).
Grau U. et al., "Combined Coenzyme-Substrate Analogues of Various Dehydrogenases"; Biochemistry, vol. 17, No. 22, pp. 4621-4626, (1978).

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