Method of fractional collection of gastric acid secretion inhibi

Details Method of fractional collection of gastric acid secretion inhibi Method of fractional collection of gastric acid secretion inhibi

1983-01-27

1984-08-28

Schain, Howard E.

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

204180G, 204180R, 424 95, 424 99, C07G 700, C07G 1500, C08H 100

Patent

active

044683448

ABSTRACT:
Gastric acid secretion inhibiting substance obtainable from mammalian urine by conventional method is fractionated into the first and second components by gel filtration, adsorption and desorption on ion exchanger or electrophoresis detecting each component by biological test methods. The activities of the two components differ from each other in the biological tests.
The first component is a glucoprotein-like substance of M.W. 100,000 and the second component is a peptide-like substance of M.W. about 6,000.

REFERENCES:
patent: 2292841 (1942-08-01), Necheles
patent: 2357103 (1944-08-01), Gray
patent: 3883497 (1975-05-01), Gregory
patent: 3912704 (1975-10-01), Singh
patent: 4190573 (1980-02-01), Zwisler et al.
patent: 4359415 (1982-11-01), Sloane
British J. of Pharmacology, 1971, 41, 8-18, Lawrence et al.

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