Method of forming particles

Details Method of forming particles Method of forming particles

2007-04-24

2007-04-24

Theisen, Mary Lynn (Department: 1732)

Plastic and nonmetallic article shaping or treating: processes

Formation of solid particulate material directly from molten...

Reexamination Certificate

active

10536330

ABSTRACT:
The present invention provides a method of forming particles that involves contacting a solution, which includes a solute and/or other material to be precipitated dissolved or dispersed in a solvent, with a first compressed or liquefied gas at an initial temperature to form a mixture. The mixture is then expanded at a first temperature to form droplets. Depending upon the composition of the droplets and the first temperature, the droplets may be in a solid state or a liquid state. The droplets are then contacted with an extracting fluid at a second temperature to extract the solvent from the droplets. The method can be used to produce micro and nanoparticles suitable for various drug delivery systems.

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patent: 5922253 (1999-07-01), Herbert et al.
patent: 6063910 (2000-05-01), Debenedetti et al.
patent: 6153129 (2000-11-01), Herbert et al.
patent: 6358443 (2002-03-01), Herbert et al.
patent: 6562952 (2003-05-01), Rajewski et al.

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