Chemistry: molecular biology and microbiology – Animal cell – per se ; composition thereof; process of... – Method of regulating cell metabolism or physiology
Reexamination Certificate
2006-05-31
2010-10-12
Bertoglio, Valarie (Department: 1632)
Chemistry: molecular biology and microbiology
Animal cell, per se ; composition thereof; process of...
Method of regulating cell metabolism or physiology
C435S373000, C435S366000, C435S372000, C435S385000
Reexamination Certificate
active
07811821
ABSTRACT:
This invention relates to the culture of dendritic cells from human embryonic stem (ES) cells. Human ES cells are first cultured into hematopoietic cells by co-culture with stromal cells. The cells now differentiated into the hematopoietic lineage are then cultured with GM-CSF to create a culture of myeloid precursor cells. Culture of the myeloid precursor cells with the cytokines GM-CSF and IL-4 causes functional dendritic cells to be generated. The dendritic cells have a unique phenotype, as indicated by their combination of cell surface markers.
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Gumenyuk Maryna E.
Slukvin Igor I.
Thomson James A.
Vodyanyk Maksym A.
Bertoglio Valarie
Quarles & Brady LLP
Wisconsin Alumni Research Foundation
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