Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Particulate form
Reexamination Certificate
2004-10-06
2010-10-12
Blanchard, David J (Department: 1611)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Particulate form
C424S400000, C424S422000, C424S427000, C424S429000, C424S501000
Reexamination Certificate
active
07811605
ABSTRACT:
The present invention relates to a method of forming shape-retentive aggregates of gel particles in which the aggregates are held together by non-covalent bond physical forces such as, without limitation, hydrophobic-hydrophilic interactions and hydrogen bonds. The method comprises introducing a suspension of gel particles in a polar liquid at a selected concentration, wherein the gel particles have an absolute zeta potential, into a medium in which the absolute zeta potential of the gel particles is decreased, resulting in the gel particles coalescing into the claimed shape-retentive aggregate. This invention also relates to uses of the method of formation of the shape-retentive aggregates of gel particles.
REFERENCES:
patent: 3822089 (1974-07-01), Wichterle
patent: 3948841 (1976-04-01), Dusek
patent: 3951925 (1976-04-01), Mishima et al.
patent: 3963685 (1976-06-01), Abrahams
patent: 4272518 (1981-06-01), Moro et al.
patent: 4542176 (1985-09-01), Graham
patent: 4962133 (1990-10-01), Chromecek et al.
patent: 5045266 (1991-09-01), Moro et al.
patent: 5122544 (1992-06-01), Bailey et al.
patent: 5266325 (1993-11-01), Kuzma et al.
patent: 5292515 (1994-03-01), Moro et al.
patent: 5468811 (1995-11-01), Moro et al.
patent: 5536508 (1996-07-01), Canal et al.
patent: 5632774 (1997-05-01), Babian
patent: 5770631 (1998-06-01), Fukutomi et al.
patent: 5840338 (1998-11-01), Roos et al.
patent: 5871722 (1999-02-01), Nacht et al.
patent: 5945457 (1999-08-01), Plate et al.
patent: 6068859 (2000-05-01), Curatolo et al.
patent: 6306177 (2001-10-01), Felt et al.
patent: 6521431 (2003-02-01), Kiser et al.
patent: 6933356 (2005-08-01), Hamamoto et al.
patent: 2003/0093157 (2003-05-01), Casares et al.
patent: 2003/0138490 (2003-07-01), Hu et al.
patent: 2004/0086548 (2004-05-01), St. John et al.
patent: 2005/0118270 (2005-06-01), Moro et al.
patent: 2008/0063716 (2008-03-01), Moro et al.
patent: 2195373 (1997-07-01), None
patent: 0 785 224 (1997-01-01), None
patent: 1 447 074 (2004-08-01), None
patent: 1 263 873 (1972-02-01), None
patent: 49-50089 (1974-05-01), None
patent: 53040038 (1978-04-01), None
patent: 58-331 (1983-01-01), None
patent: 58149910 (1983-09-01), None
patent: 05247225 (1993-09-01), None
patent: 9-25303 (1997-01-01), None
patent: 9-208710 (1997-08-01), None
patent: 2001-517494 (2001-10-01), None
patent: 2002284882 (2002-10-01), None
patent: 2002302616 (2002-10-01), None
patent: 2003261777 (2003-09-01), None
patent: WO 99/15211 (1999-04-01), None
patent: WO 03/026537 (2003-04-01), None
patent: WO 2006/041967 (2006-04-01), None
Zeta-Meter, Inc. Zeta Potential: A Complete Course in 5 Minutes. Accessed from http://www.zeta-meter.com/5min.pdf via the Wayback Machine (Jun. 6, 2001).
Ruckenstein et al, Polymerization in gel-like emulsions, J. of Applied Polymer Science, vol. 36, pp. 907-923, 1988.
am Ende, et al., “Transport of ionizable drugs and proteins in crosslinked poly(acrylic acid) and poly(acrylic acid-co-2-hydroxyethyl methacrylate)”Journal of Controlled Release(1997) 48:47-56.
Ayhan, F. et al., “Optimization of urease immobilization onto non-porous HEMA incorporated poly(EGDMA) microbeads and estimation of kinetic parameters”Bioresource Technology(2002) 81:131-140.
Beers, K. L. et al., “Atom Transfer Radical Polymereization of 2-Hydroxyethyl Methacrylate”Macromolecules(1999) 32:5772-5776.
Bouillaguet, S. et al., “Effect of sub-lethal concentrations of HEMA (2-hydroxyethyl methacrylate) on THP-1 human monocyte-macrophages, in vitro”Dental Materials(2000) 16:213-217.
Brahim, S. et al., “Kinetics of glucose oxidase immobilized in p(HEMA)-hydrogel microspheres in a packed-bed bioreactor”Journal of Molecular Catalysis B: Enzymatic(2002) 18:69-80.
Brier-Russell, D. et al., “In Vitro Assessment of Interaction of Blood with Model Surfaces: Acrylates and Methacrylates”Journal of Colloid and Interface Science(1981) 81:311-318.
Dalton, P. D. et al., “Manufacture of poly(2-hydroxyethyl methacrylate-co-methyl methacrylate) hydrogel tubes for use as nerve guidance channels”Biomaterials(2002) 23:3843-3851.
Debord, J.D. et al., “Thermoresponsive Photonic Crystals”The Journal of Physical Chemistry(2000) 104(27):6327-6331.
Denizli, A. et al., “Monosize and non-porous p(HEMA-co-MMA) microparticles designed as dye- and metal-chelate affinity sorbents”Colloids and Surfaces A: Physicochemical and Engineering Aspects(2000) 174:307-317.
Dziubla, T. D. et al., “Evaluation of porous networks of poly(2-hydroxyethyl methacrylate) as interfacial drug delivery devices”Biomaterials(2001) pp. 2893-2899.
Frutos, P. et al., “Release of gentamicin sulphate from a modified commercial bone cement. Effect of (2-hydroxyethyl methacrylate) comonomer and poly(N-vinyl-2-pyrrolidone) additive on release mechanism and kinetics”Biomaterials(2002) 23:3787-3797.
Gallardo, A. et al., “Controlled release of cyclosporine from VP-MEMA copolymer systems of adjustable resorption monitorized by MEKC”Biomaterials(2000) 21:915-921.
Gallardo, A. et al., “Modulated release of cyclosporine from soluble vinyl pyrrolidone-hydroxyethyl methacrylate copolymer hydrogels A correlation of ‘In vitro’ and ‘in vivo’ experiments”Journal of Controlled Release(2001) 72:1-11.
Garrett, Q. et al., “Effect of charged groups on the adsorption and penetration of proteins onto and into carboxymethylated poly(HEMA) hydrogels”Biomaterials(1998) 19:2175-2186.
Graham, N. B. et al., “Nanogels and microgels: The new polymeric materials playground”Pure&Appl. Chem. (1998) 70(6):1271-1275.
Hacioglu, B. et al., “Polymerization kinetics of HEMA/DEGDMA: using changes in initiation and chain transfer rates to explore the effects of chain-length-dependent termination”Biomaterials(2002) 23:4057-4064.
Horak, D. et al., “Hydrogels in endovascular embolization”Biomaterials(1997) 18:1355-1359.
Hsiue, G. et al., “Poly(2-hydroxyethyl methacrylate) film as a drug delivery system for pilocarpine”Biomaterials(2001) 22:1763-1769.
Hu, Z. et al., “Polymer Gel Nanoparticle Networks”Advanced Materials(2000) 12(16):1173-1176.
Hutcheon, G.A. et al., “Water absorption and surface properties of novel poly(ethylmethacrylate) polymer systems for use in bone and cartilage repair”Biomaterials(2001) 22:667-676.
Klisch, J. et al., “Combined stent implantation and embolization with liquid 2-polyhydroxyethyl methacrylate for treatment of experimental canine wide-necked aneurysms”Interventional Neuroradiology(2002) 44:503-512.
Lesny, P. et al., “Polymer hydrogels usable for nervous tissue repair”Journal of Chemical Neuroanatomy(2002) 23:243-247.
Liu, Q. et al., “Preparation of macroporous poly(2-Hydroxyethyl methacrylate) hydrogels by enhanced phase separation”Biomaterials(2000) 21:2163-2169.
Lyon, L. A. et al., “Responsive Microgel Photonic Crystals”Polymer Preprints(2002) 43:24-25.
Lyon, L. A. et al., “Tunable Kinetics of Core-Shell Microgel Volume Phase Transitions”Polymer Preprints(2002) 43:363-364.
Noda, M. et al., “Sublethal, 2-week exposures of dental material components alter TNF-α secretion of THP-1 monocytes”Dental Materials(2003) pp. 1-5.
Nojiri, C. et al., “Nonthrombogenic Polymer Vascular Prosthesis”Artificial Organs(1995) 19(1):32-38.
Pashley, D. H. et al., “Permeability of demineralized dentin to HEMA”Dental Materials(2000) 16:7-14.
Ramakrishna, S. et al., “Biomedical applications of polymer-composite materials: a review”Composites Science and Technology(2001) 61:1189-1224.
Reichl, F. X., “Biological clearance of HEMA in guinea pigs”Biomaterials(2002) 23:2135-2141.
Robinson, K. L., “Controlled Polymerization of 2-Hydroxyethyl Methacrylate by ATRP at Ambient Temperature”Macromolecules(2001) 34:3155-3158.
Rogach, A.
Moro Daniel G.
Ponder Bill C.
Shannon Kevin F.
St. John John V.
Blanchard David J
Foley & Lardner LLP
Konski Antoinette F.
ULURU Inc.
Welter Rachael E
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