Plastic and nonmetallic article shaping or treating: processes – Mechanical shaping or molding to form or reform shaped article – To produce composite – plural part or multilayered article
Patent
1997-07-23
1999-10-19
Ortiz, Angela
Plastic and nonmetallic article shaping or treating: processes
Mechanical shaping or molding to form or reform shaped article
To produce composite, plural part or multilayered article
264275, 206455, B29C 4515, B29C 7070
Patent
active
059684364
DESCRIPTION:
BRIEF SUMMARY
TECHNICAL FIELD
This invention relates to a method of fixedly supporting a biopsy specimen in an embedding cassette without permitting it to be degraded, of all the processes necessary for the diagnosis of a disease or determination of a treatment for the disease, the method comprises sampling a biopsy specimen from human body, embedding it and preparing a thin section slide therefrom to be inspected microscopically in a pathological laboratory. This invention also relates to an embedding cassette and a fixedly supporting agent necessary for execution of the method.
BACKGROUND ART
Conventionally, when engaged in a work necessary to achieve the object as described above, the clinician places a biopsy specimen into a flat cassette with a lid made of an opaque porous plate, closes the lid, puts the cassette into a capsule where an antiseptic agent has been placed that prevents the specimen from degrading, and sends the capsule to a pathological laboratory for inspection.
In the pathological laboratory, the tester takes out the embedding cassette from the capsule, opens the lid of the cassette, and compares the biopsy specimen therein with the description on a bill attached to the specimen, to confirm that the specimen properly coincides with the description. Then, he places again the specimen into the cassette, puts it in a vessel containing alcohol or xylene, and submits it to processes comprising dehydration, removal of fat, removal of alcohol, and immersing it in an embedding agent consisting of paraffin or a resin in succession.
Then, the tester opens the lid of the embedding container, picks up the biopsy specimen directly with a pair of forceps, and transfers it to another embedding plate prepared in advance. He places the bottom of the embedding cassette which is made of a porous plate above the biopsy specimen placed on the embedding plate, with some spacing there between, and pours an embedding agent consisting of molten paraffin or resin over the bottom, to embed the biopsy specimen together with a part of the embedding cassette with the embedding agent. In this state, the embedding agent is allowed to cool so that the biopsy specimen embedded together with the part of the embedding cassette in the embedding agent is hardened to form an embedded block.
Then, the pathologist cuts the biopsy specimen kept in the embedded block with a microtome together with the embedding agent, into thin sections, and examines them with a microscope.
The above described processes employing the conventional embedding cassette have following problems which remain to be improved.
Firstly, during embedding operation, the biopsy specimen is picked up directly with forceps before it is transferred to the embedding plate. This operation may distort the specimen locally by pressure, and inflict damages thereupon, which may interfere with proper treatment of the specimen for laboratory inspection.
Secondarily, if a plurality of specimens are placed in the embedding cassette in the order of sampling or according to sampled sites, they may be placed in a different arrangement from the original one by accident when they are transferred to a separate embedding plate. Further, while they are transferred to a separate embedding plate, they may be wrongly intermingled with biopsy specimens from a different embedding cassette, or some of them may be exchanged for wrong specimens from a different cassette. If such wrong operations happen, they would bring a grave effect on the results of microscopic inspection which takes place following the transference.
Thirdly, after being embedded, a part of the biopsy specimen necessary for inspection is cut by the pathologist with a microtome into thin sections which are then observed by microscopy. However, as the technician who is responsible for embedding the biopsy specimen and the pathologist are generally different persons, the technician finds it difficult to locate the part of the specimen which the pathologist would desire to inspect, and thus finds it difficult to place the biopsy s
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