Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-02-24
1989-04-18
Friedman, Stanley J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514349, A61U 3144, A61U 31445
Patent
active
048228028
ABSTRACT:
A method of postoperative pain relief using transdermal delivery of fentanyl or its analgetically effective derivatives preceded by a dose of said material to increase the serum drug levels to steady state more quickly.
REFERENCES:
patent: 4588580 (1986-05-01), Gale et al.
Chem. Abst. 104 (1986) 213272t.
Physician's Desk Reference, pp. 1033-1035, 1987 edition.
F. O. Holley et al., "Transdermal Administration of Fentanyl for Postoperative Analgesia," Anesthesiology, v. 65 (3A), Sep. 1986.
W. S. Nimmo et al., "Plasma Fentanyl Concentrations After Transdermal or I.V. Infusion of Fentanyl", Anesthesiology, v. 65 (3A), Sep. 1986.
D. J. R. Duthie et al., "The Pharmacokinetics of Fentanyl by Constant Rate I.V. Infusion for Pain Relief After Surgery," Anesthesiology, V. 63(3A), Sep. 1985.
W. S. Nimmo et al., "Fentanyl by Constant Rate I.V. Infusion for Postoperative Analgesia," Br. J. Anaesth., v. 57, pp. 250-254 (1985).
D. J. R. Duthie et al., "Pharmacokinetics of Fentanyl During Constant Rate I.V. Infusion for the Relief of Pain After Surgery," Br. J. Anaesth., v. 58, pp. 950-956 (1986).
Plezia et al., "Transdermal Therapeutic System (Fentanyl) for Postoperative Pain: An Efficacy, Toxicity, and Pharmacokinetic Trail.", ASA Abstracts, A210, (Sep. 1986), Anesthesiology, vol. 65 (3A).
Caplan et al., "Transdermal Delivery of Fentanyl for Postoperative Pain Control", (Sep. 1986), Anesthesiology, vol. 65 (3A).
H. Stoeckel et al., "Pharmacokinetics of Fentanyl as a Possible Explanation for Recurrence of Respiratory Depression," Br. J. Anaesth. 51, pp. 741-744, (1979).
Levy Gerhard
Powers Cramer Marilou S.
Southam Mary
ALZA Corporation
Friedman Stanley J.
Mandell Edward L.
Precivale Shelley G.
Stone Steven F.
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