Method of facilitating detection of amino acid derivatives with

Details Method of facilitating detection of amino acid derivatives with Method of facilitating detection of amino acid derivatives with

1988-08-10

1991-04-16

Hill, Jr., Robert J.

Chemistry: analytical and immunological testing

Peptide, protein or amino acid

Amino acid or sequencing procedure

436 92, 436174, 530345, 530402, G01N 3368

Patent

active

050082051

ABSTRACT:
A method of detecting and identifying amino acid derivatives produced by sequential cleavage of N-terminal residues from a polypeptide chain. The polypeptide is first reacted with an isothiocyanate to produce an N-terminal-thiocarbamyl polypeptide. This derivative is then cleaved to form a cyclic ATZ derivative, which is subsequently combined with a detectable alcohol in anhydrous acid to primarily produce a stable thiocarbamyl amino acid ester. This compound may be readily detected and identified.

REFERENCES:
patent: 4863870 (1989-09-01), Stolowitz et al.
patent: 4865994 (1989-09-01), Tsugita et al.

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