Method of fabricating a tissue engineering scaffold

Details Method of fabricating a tissue engineering scaffold Method of fabricating a tissue engineering scaffold

2011-08-16

2011-08-16

Johnson, Christina (Department: 1742)

Plastic and nonmetallic article shaping or treating: processes

Pore forming in situ

By treating occluded solids

C264S413000, C264S036110, C264S037150, C264S048000, C264S3420RE, C264S3420RE, C264S086000, C264S288800, C264S916000, C264S645000, C264S513000, C264S537000, C264S297200

Reexamination Certificate

active

07998380

ABSTRACT:
A method of fabricating a highly porous structure is provided. The method includes the step of compounding a biodegradable polymer, a water-soluble polymer and a porogen to form a composite blend. A foaming agent is dissolved into the composite blend and the composite blend is injected into a mold so as to form the structure. Thereafter, the structure is removed from the mold and leached in a fluid.

REFERENCES:
patent: 3730918 (1973-05-01), Teti et al.
patent: 5679723 (1997-10-01), Cooper et al.
patent: 6103255 (2000-08-01), Levene et al.
patent: 6306424 (2001-10-01), Vyakarnam et al.
patent: 6322347 (2001-11-01), Xu
patent: 6333029 (2001-12-01), Vyakarnam et al.
patent: 6365149 (2002-04-01), Vyakarnam et al.
patent: 6534084 (2003-03-01), Vyakarnam et al.
patent: 6626950 (2003-09-01), Brown et al.
patent: 6692761 (2004-02-01), Mahmood et al.
patent: 6746685 (2004-06-01), Williams
patent: 6773713 (2004-08-01), Bonassar et al.
patent: 6852330 (2005-02-01), Bowman et al.
patent: 6884428 (2005-04-01), Binette et al.
patent: 7112417 (2006-09-01), Vyakarnam et al.
patent: 2004/0010048 (2004-01-01), Evans et al.
patent: 2004/0026811 (2004-02-01), Murphy et al.
patent: 2005/0107868 (2005-05-01), Nakayama et al.
patent: 2005/0165475 (2005-07-01), Noh
patent: 2006/0002978 (2006-01-01), Shea et al.
patent: 2006/0083771 (2006-04-01), Yamamoto et al.
patent: 2006/0153814 (2006-07-01), Liao et al.
Shao, Xin Xin, et al., Evaluation of a hybrid scaffold/cell construct in repair of high-load-bearing osteochondral defects in rabbits, Biomaterials 27 (2006) pp. 1071-1080, Elsevier, Cambridge, MA.
Nho, Shane J. et al., Patellofemoral Osteochondral Autologous Transfer, Techniques in Knee Surgery 5(2), pp. 134-137, 2006, Lippincott Williams & Wilkins, Philadephia, PA.
Mikos, Antonios G., et al., Preparation and characterization of poly (L-lactic acid) foams, Polymer, vol. 35 No. 5, 1994 pp. 1068-1077, Butterworth-Heinemann Ltd., Burlington, MA.
Mooney, David J., et al., Novel approach to fabricate porous sponges of poly (D,L-lactic-co-glycolic acid) without the use of organic solvents, Biomaterials 17 (1996) 1417-1422, Elsevier, Cambridge, MA.
Nam, Yoon Sung, et al., A novel fabrication method of macroporous biodegradable polymer scaffolds using gas foaming salt as a porogen additive, Journal of Biomedical Materials Research (Applied Biomaterials) 53:1-7, 2000 John Wiley & Sons, Inc., Hoboken, NJ.
Harris, Leatrese, et al., Open Pore Biodegradable matrices formed with gas foaming, Journal of Biomedical Materials Research, vol. 42, No. 3, Dec. 5 1998. pp. 396-402, 2000, John Wiley & Sons, Inc., Hoboken, NJ.
Washburn, Newell R ., et al., Co-extrusion of biocompatible polymers for scaffolds with co-continuous morphology, Journal of Biomedical Materials Research, vol. 60, No. 1, pp. 20-29, 2002, John Wiley & Sons, Inc., Hoboken, NJ.
Wang, Xiaoxi, et al., Solvent Free Fabrication of Biodegradable Porous Polymers, Proceedings of Imece04, pp. 595-602, 2204, American Society of Mechanical Engineers, New York, New York.
Wu, Linbo, et al., a “room-temperature” injection molding/particulate leaching approach for fabrication of biodegradable three-dimensional porous scaffolds, Biomaterials, 27 (2006) pp. 185-191, Elsevier, Cambridge, MA.
Leicher, S., et al., MuCell® technology for injection molding: A processing method for polyether-urethane scaffolds, Journal of Materials Science, 40 (17): 4613-4618, 2005, Springer Science + Business Media, Inc., New York, New York.
Reignier, Joel, et al., Preparation of Interconnected Polycaprolactone Porous Scaffolds by a Combination Polymer and Salt Particulate Leaching, Proceedings of ANTEC 2005, pp. 2550-2554, Society of Plastics Engineers, Brookfield, CT.
Neves, Nuno M., et al., The morphology, mechanical properties and ageing behavior of porous injection molded starch-based blends for tissue engineering scaffolding, Materials Science & Engineering, C 25 (2205) pp. 195-200, Elsevier, Cambridge, MA.
Haugen, H. et al., A Novel Processing Method for Injection-Molded Polyether-Urethane Scaffolds. Part 1: Processing, Journal of Biomedical Materials Research Part B—Applied Biomaterials, vol. 77B , No. 1 (Apr. 2006), pp. 65-72, Wiley-Liss , Div John Wiley & Sons Inc, Hoboken, NJ.

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