Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Reexamination Certificate
2005-09-27
2005-09-27
Azpuru, Carlos A. (Department: 1615)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
Reexamination Certificate
active
06949253
ABSTRACT:
An implantable biocompatible microchip drug delivery substrate is coated with a thin film of ultra-nanocrystalline diamond; assuring that the device is biocompatible and impermeably sealed, to prevent the substrate from being dissolved by the living tissue and to protect the drugs from premature release or undesired reaction with the body fluids. The coating is selectively patterned by doping to create electrically conductive areas that can be used as an electrically activated release mechanism for drug delivery. The conformal ultra-nanocrystalline diamond coating uniformly covers the device, providing relief from sharp edges and producing a strong, uniformly thick impermeable coating around sharp edges and on high aspect-ratio parts. The ultra-nanocrystalline diamond coating provides a conformal coating on the biocompatible device, which is of approximately uniform thickness around sharp corners and on high aspect-ratio parts. The conformal nature of the coating assures impermeability and strength despite the presence of difficult to coat shapes.
REFERENCES:
patent: 4991582 (1991-02-01), Byers et al.
patent: 5750926 (1998-05-01), Schulman et al.
patent: 5797898 (1998-08-01), Santini et al.
patent: 6123861 (2000-09-01), Santini, Jr. et al.
D. M. Zhou, et al., “Accelerated Corrosion Tests on Silicon Wafer for Implantable Medial Devices”, Proc. of 198th Electrochemical Society Meeting, 363, Oct. 2000.
D. M. Gruen, “Nanocrystalline Diamond Fims”Annu. Rev. Mater.Sci., 29 211-59 (199).
D. M. Gruen et al. “Buckyball Microwave Plasmas: Fragmentation and Diamond Film Growth”, J. Appl. Phys., 75(3) 1758-63 (1994).
Greenberg Robert J.
Mech Brian V.
Azpuru Carlos A.
Dunbar Scott B.
Schnittgrund Gary D.
Second Sight Medical Products, Inc.
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