Method of extracting sennosides A, B and A1

Details Method of extracting sennosides A, B and A1 Method of extracting sennosides A, B and A1

1995-12-21

1998-01-20

Kight, John

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4241951, 514783, 536124, 536127, 536128, C07H 15244, C07H 100, A61K 3578

Patent

active

057102600

ABSTRACT:
Sennosides A, B and Al of the formula: ##STR1## which are substantially free from sennosides C, D and Dl, and from aloe-emodin derivatives, are prepared by a process wherein
a) a sennoside mixture is reduced to rhein-9-anthrone-8-glucoside and aloe-emodin-9-anthrone-8-glucoside,
b) a liquid-liquid partitioning of the compounds obtained is carried out between a polar organic solvent which is only partly miscible with water and an aqueous phase and
c) the rhein-9-anthrone-8-glycosides contained after the partitioning in the aqueous phase is again oxidized to the corresponding sennosides and these are recovered.

REFERENCES:
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patent: 4595592 (1986-06-01), Hietala
patent: 5232699 (1993-08-01), Colliopoulos
patent: 5234916 (1993-08-01), Hord
patent: 5391775 (1995-02-01), Carcasona et al.
patent: 5393898 (1995-02-01), Carcasona et al.
Leng--Peschlow, E. J. Pharm. Pharmacol., vol. 32(5), pp. 330-35, (1980).
Kobashi, Kyoichi et al. Chem. Pharm. Bull., 35(5), pp. 1998-2003, (1987).

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