Method of expressing an exogenous nucleic acid

Details Method of expressing an exogenous nucleic acid Method of expressing an exogenous nucleic acid

1999-06-08

2000-12-26

Schwartzman, Robert A.

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Recombinant dna technique included in method of making a...

4353201, 435455, 514 44, 536 231, 536 241, C12P 2100, C12N 1563, C12N 1585, A61K 4800, C07H 2104

Patent

active

061657549

ABSTRACT:
The present invention provides a method of expressing an exogenous nucleic acid in a mammal. The method comprises non-systemically administering to a non-neuronal tissue of said mammal an exogenous nucleic acid operatively linked to a promoter. The exogenous nucleic acid is proximal to at least one native parvoviral inverted terminal repeat and does not require encapsidation. The expression of the exogenous nucleic acid in the tissue is not substantially diminished at 28 days after administration of the exogenous nucleic acid.

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