Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Cosmetic – antiperspirant – dentifrice
Reexamination Certificate
2011-06-07
2011-06-07
Schnizer, Richard (Department: 1617)
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Cosmetic, antiperspirant, dentifrice
C514S625000, C356S030000, C564S192000
Reexamination Certificate
active
07955607
ABSTRACT:
Provided are a method for evaluating evenness of suplatast tosilate crystals; stable suplatast tosilate crystals exhibiting evenness in optical purity; and a method for producing the suplatast tosilate crystals.The method for evaluating evenness of suplatast tosilate crystals includes: (a) a step of adding a solvent to suplatast tosilate crystals to thereby dissolve 3% or less of the crystals in the solvent, and subjecting a portion of the supernatant of the resultant suspension to optical purity measurement, and (b) a step of adding a solvent to the remaining suspension to thereby dissolve the entirety of the suspension in the solvent, and subjecting a portion of the resultant solution to optical purity measurement, wherein the optical purity as measured in the step (a) is compared with the optical purity as measured in the step (b). The suplatast tosilate crystals exhibits excellent evenness and thermal stability. The method for producing the suplatast tosilate crystals is also provided.
REFERENCES:
patent: 5286858 (1994-02-01), Moriwaki et al.
patent: 6458798 (2002-10-01), Fujita et al.
patent: 2003/0149105 (2003-08-01), Ushio et al.
patent: 59-167564 (1984-09-01), None
patent: 07-252213 (1995-10-01), None
patent: 02/083633 (2002-10-01), None
patent: WO02083633 (2002-10-01), None
JP-A-1995-252213, Takanori et al., published Mar. 1995. NPL machine translation attached.
Addadi, et al. “Useful Impurities for Optical Resolutions.” J. Am. Chem. Soc. 1981, 103, 1249-1251.
Takanori Ushio, et al., Polymorphism of an anti-allergic agent suplatast tosilate by Tailor Made Additives, Proceedings of the 122ndAnnual Meeting of the Pharmaceutical Society of Japan, vol. 3, 26[P] II-193, 26[P] II-194, 26[P] II-195, p. 7 (with English translation), (2002).
Rui Tamura, et al., “Mechanism of Preferential Enrichment, an Unusual Enantiomeric Resolution Phenomenon Caused by Polymorphic Transition during Crystallization of Mixed Crystals Composed of Two Enantiomers”, J. Am. Chem. Soc., vol. 124, No. 44, 2002, pp. 13139-13153.
Takanori Ushio, et al., Unusual Enantiomeric Resolution Phenomenon Observed upon Recrystallization of a Racemic Compound, Angew. Chem. Int. Ed. Engl., vol. 35, No. 20, 1996, pp. 2372-2375.
Nagai Keiko
Ushio Takanori
Buckley Audrea J
Oblon, Spivak McClelland, Maier & Neustadt, L.L.P.
Schnizer Richard
Taiho Pharmaceutical Co. Ltd.
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