Method of evaluating drug efficacy and toxicity

Details Method of evaluating drug efficacy and toxicity Method of evaluating drug efficacy and toxicity

2006-05-23

2006-05-23

Horlick, Kenneth R. (Department: 1637)

Chemistry: molecular biology and microbiology

Micro-organism, tissue cell culture or enzyme using process...

Preparing compound containing saccharide radical

C435S091100, C435S006120

Reexamination Certificate

active

07049103

ABSTRACT:
A method of assaying the efficacy and/or toxicity of a test substance by expression of a specific gene in a cell or a microorganism, which comprises treating the cell or the microorganism with the test substance, a step of amplifying an RNA having a sequence homologous or complementary to a specific sequence in a target RNA obtained as the result of transcription of the specific gene, and a step of determining whether the target RNA is transcribed through the expression of the specific gene by detecting the RNA amplified in the previous amplification step.

REFERENCES:
patent: 5814447 (1998-09-01), Ishiguro et al.
patent: 6030115 (2000-02-01), Ishiguro et al.
patent: 6063572 (2000-05-01), Ishiguro et al.
patent: 6211354 (2001-04-01), Horie et al.
patent: 0 534 640 (1993-03-01), None
patent: 0 969 101 (2000-01-01), None
patent: WO 97/13877 (1997-04-01), None
patent: WO 99/47709 (1999-09-01), None
Burcynski et al. Drug Metabolism and Disposition. vol. 29, No. 9, pp. 1243-1250, Sep. 2001.
Nakahara et al. Nucleic Acids Research, vol. 26, No. 7, pp. 1854-1855, Apr. 1998.
Patent Abstracts of Japan, JP 11-000199, Jan. 6, 1999, Abstract only.
M. E. Burczynski, et al., Drug Metabolism and Disposition, vol. 29, No. 9, XP-002255571, pp. 1243-1250, “Cytochrome P450 Induction in Rat Hepatocytes Assessed by Quantitative Real-Time Reverse-Transcription Polymerase Chain Reaction and the RNA Invasive Cleavage Assay”, Sep. 2001.
H. Myoung, et al., Cancer Letters, vol. 163, No. 2, XP-002255572, pp. 191-200, “Evaluation of the Anti-Tumor and Anti-Angiogenic Effect of Paclitaxel and Thalidomide on the Xenotransplanted Oral Squamous Cell Carcinoma”, Feb. 26, 2001.

Affiliated with

Also associated with

Rating

Method of evaluating drug efficacy and toxicity does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of evaluating drug efficacy and toxicity, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of evaluating drug efficacy and toxicity will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-3634304