Method of evaluating chromosome state and evaluation system

Details Method of evaluating chromosome state and evaluation system Method of evaluating chromosome state and evaluation system

2004-07-29

2010-11-23

Clow, Lori A (Department: 1631)

Data processing: measuring, calibrating, or testing

Measurement system in a specific environment

Biological or biochemical

C382S128000, C382S133000, C382S282000, C382S286000

Reexamination Certificate

active

07840357

ABSTRACT:
A method of evaluating a cell state based on information of an image taken of a cell containing a chromosome territory is provided. This method includes extracting the chromosome territory from the image (S20), standardizing a positioning state of the chromosome territory and then quantifying the positioning state (S22), and evaluating the cell state based on the quantified positioning state of the chromosome territory (S26).

REFERENCES:
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A. P. Dempster, N. M. Laird, and D. B. Rubin; “Maximum Likelihood from Incomplete Data via theEMAlgorithm”; J. Roy. Stat. Soc.; 1977; vol. 30; pp. 205-248.
Luis A. Parada, et al. “Chromosome Positioning in the Interphase Nucleus,” Trends in Cell Biology, vol. 12, No. 9, Sep. 2002.
Hideyuki Tanaba, “Chromosome Territory: Recent Advancement of Studies on Interphase Chromosome Positioning in Relation to Nuclear Architecture,” Environmental Mutagen Research, vol. 25, No. 1, 2003.
T. Cremer, et al. “Chromosome Territories, Nuclear Architecture and Gene Regulation in Mammalian Cells,” Nature Reviews, Genetics, vol. 2, Apr. 2001.

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