Chemistry: molecular biology and microbiology – Process of utilizing an enzyme or micro-organism to destroy... – Resolution of optical isomers or purification of organic...
Reexamination Certificate
2011-07-05
2011-07-05
Saucier, Sandra (Department: 1651)
Chemistry: molecular biology and microbiology
Process of utilizing an enzyme or micro-organism to destroy...
Resolution of optical isomers or purification of organic...
C435S119000
Reexamination Certificate
active
07972836
ABSTRACT:
The present invention relates to a method for preparing an optically active 4-hydroxy-1,2,3,4-tetrahydroquinoline compound [I], which comprises the steps of:treating a racemic 4-hydroxy-1,2,3,4-tetrahydroquinoline compound represented by general formula [I]:[wherein R1represents a hydrogen atom or a protecting group for amino group.]with an enzyme having an ability of selectively or preferentially acylating one enantiomer of the racemic compound [I] in the presence of an acyl donor; andif necessary, subjecting the reaction product to solvolysis.
REFERENCES:
patent: 0 748 805 (1996-12-01), None
patent: 7-184685 (1995-07-01), None
patent: 8-322591 (1996-12-01), None
patent: 2001-149089 (2001-06-01), None
European Search Report dated Sep. 23, 2010.
Kishida Muneki
Mori Yoshikazu
Okamoto Masaki
Sakuragi Akira
Finnegan Henderson Farabow Garrett & Dunner L.L.P.
Mitsubishi Tanabe Pharma Corporation
Saucier Sandra
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