Method of enzymatic debridement

Details Method of enzymatic debridement Method of enzymatic debridement

1981-05-05

1982-11-30

Rosen, Sam

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

A61K 3748

Patent

active

043615511

ABSTRACT:
A method of treating devitalized tissue in mammals is disclosed. The method comprises applying to the devitalized tissue a composition comprising an enzyme mixture derived from crude bromelain which exhibits 15 to 35 units of protease activity per milligram of protein in the presence of cysteine and from 0.5 to 5 units of collagenase activity per milligram of protein and an inert solvent carrier containing at least 60 percent water.

REFERENCES:
patent: 4197291 (1980-04-01), Klein et al.
Silverstein et al., Surgery, 73 (1) pp. 15-22 (Jan. 1973).
Levine et al., Plastic and Reconstr. Surgery, 52 (4) pp. 413-424 (Oct. 1973).
Levinson et al., Ann. Surg., 180 (4) pp. 670-704 (1974).

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