Method of enrichment of coagulation factors II, VII, IX and X

Details Method of enrichment of coagulation factors II, VII, IX and X Method of enrichment of coagulation factors II, VII, IX and X

1989-07-20

1991-12-10

Draper, Garnette D.

Chemistry: natural resins or derivatives; peptides or proteins;

Proteins, i.e., more than 100 amino acid residues

Blood proteins or globulins, e.g., proteoglycans, platelet...

530381, 530416, C07K 302, C07K 322

Patent

active

050719610

ABSTRACT:
A method of enrichment of coagulation Factors II, VII, IX and X in preparations obtained from plasma, plasma fractions, or other liquids containing the factors, by adsorbing the factor or factors onto a polymeric matrix that carries an .alpha.-hydroxylamine group, and eluting the factors. When the chromatography conditions are appropriate, it is also easy to prepare a highly concentrated Factor IX preparation with a purity of more than 10 U per mg of protein.

REFERENCES:
patent: 4481189 (1984-11-01), Prince
CA107:161669t Smith, K. J. (Blood Systems, Inc.) Eur. Pat. Appln. EP229,026 15 Jul. 1987. Matsumoto et al. (1980) J. Biochem. 87, 535-540.

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