Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1994-04-20
1996-10-01
Russel, Jeffrey E.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
514 13, 530324, 530326, 530345, 43524031, A61K 3810, A61K 3816, C07K 708, C07K 1400
Patent
active
055611079
ABSTRACT:
A method of treating a wound of a mammalian subject in need of such treatment, to promote healing thereof, comprising administering to the subject, e.g., to the wound locus, a composition comprising a fibroblast and keratinocyte proliferatingly effective amount of an amphipathic peptide, preferably an amphipathic peptide which is antimicrobially effective at such locus. A method is also disclosed of stimulating the accelerated growth of dermal tissue in a tissue culture containing same, comprising applying to the tissue culture a fibroblast and keratinocyte proliferatingly effective amount of an amphipathic peptide, by which the dermal tissue may be grown to produce skin for skin grafting purposes, utilizing a dermal tissue culture containing dermal tissue material of a skin graft recipient of such skin. Novel amphipathic peptides suitable for use in such methods are disclosed.
REFERENCES:
patent: 4355104 (1982-10-01), Hultmark et al.
patent: 4520016 (1985-05-01), Hultmark et al.
patent: 4810777 (1989-03-01), Zasloff
patent: 4940666 (1990-07-01), Boyce et al.
patent: 5045531 (1991-09-01), Berkowitz et al.
patent: 5070188 (1991-12-01), Njieha et al.
patent: 5186166 (1993-02-01), Riggs et al.
patent: 5242902 (1993-09-01), Murphy et al.
patent: 5294605 (1994-03-01), Houghten et al.
patent: 5411942 (1995-05-01), Widmer et al.
patent: 5424290 (1995-05-01), Maloy et al.
Biochemistry, vol. 7, No. 6, issued Jun. 1968, Means et al, "Reductive Alkylation of Amino Groups in Proteins", pp. 2192-2201.
Cell, vol. 23, issued Mar. 1981, Rozengurt et al, "Melittin Stimulates Na Entry". . . , pp. 781-788.
J. Biol. Chem., vol. 243, No. 23, issued 10 Dec. 1968, Takahashi, "The Reaction of Phenylglyoxal with Arginine . . . ", pp. 6171-6179.
Jaynes, J. M., et al. "In Vitro Cytocidal Effect Of Lytic Peptides On Several Transformed Mammalian Cell Lines", Peptide Research, 2:157-160 (1989).
Jaynes, J. M. "Lytic Peptides Portend An Innovation Age In The Management And Treatment Of Human Disease", Drug News and Perspectives, 3:69-78 (1990).
Akerfeldt, et al. "Synthetic Peptides As Models For Ion Channel Proteins", Acc. Chem. Res., 26:191-197 (1993).
Reed, W. A., et al. "Enhanced In Vitro Growth Of Murine Fibroblast Cells And Preimplantation Embryos Cultured In Medium Supplemented With An Amphipathic Peptide," Molecular Reproduction and Development 31:106-113 (1992).
Arrowood, M. J., et al. "Hemolytic Properties Of Lytic Peptides Active Against The Sporozites Of Cryptosporidium Parvum," J. Protozool. 38:161s-163s (1991).
Jaynes, J. M. et al. "In Vitro Effect Of Novel Lytic Peptides On Plasmodium Falciparum And Trypanosoma Cruzi," Faseb J. 2:2878-2883 (1988).
Graham, M. L. et al. "Cytotoxic Effect Of Amphipathic Cationic Lytic Peptides On Human And Murine Cancer Cell Lines", Proceedings of the American Association for Cancer Research 35:410 (1994).
"Preliminary Experimental Anti-Cancer Activity Of Cecropin B," Proceedings of the American Association for Cancer Research 35:410 (1994).
Jaynes Jesse M.
Julian Gordon R.
Demeter Biotechnologies, Ltd.
Russel Jeffrey E.
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