Method of enhancing the regeneration of injured nerves and adhes

Details Method of enhancing the regeneration of injured nerves and adhes Method of enhancing the regeneration of injured nerves and adhes

1992-09-08

1994-01-18

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Hydrolases

424530, 514 2, 514 21, A61K 3754

Patent

active

052798259

ABSTRACT:
The regeneration of injured nerves is enhanced by supplying collagenase to the zone of injury of the nerve. Growth of nerve sprouts over the zone of injury is aided by the presence of effective amounts of collagenase during the regeneration process. If the nerve has been severed, collagenase is supplied to the ends of the proximal and distal stumps. A nerve graft may be interposed between the stumps. Natural fibrin has been used as glue to join nerve stumps, and collagenase is effective when used in admixture with fibrin.

REFERENCES:
patent: 4983393 (1991-01-01), Cohen et al.
patent: 5045601 (1991-09-01), Capelli et al.
Copelas et al., Pflugers Arch 408(3):315-317 (1987).

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