Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Recombinant dna technique included in method of making a...
Reexamination Certificate
2006-03-07
2006-03-07
O'Hara, Eileen B. (Department: 1646)
Chemistry: molecular biology and microbiology
Micro-organism, tissue cell culture or enzyme using process...
Recombinant dna technique included in method of making a...
C435S348000, C435S254200, C435S252330, C435S360000, C435S365100, C435S320100, C536S023500, C530S399000, C514S002600, C514S012200, C424S134100, C424S192100
Reexamination Certificate
active
07008781
ABSTRACT:
Novel fusion polypeptide ligands that bind Eph family receptors or the Tie-2 receptor are identified, and methods for making the fusion polypeptide ligands in biologically active form are described. Nucleic acids encoding these novel fusion polypeptide ligands enable production of the fusion polypeptide ligands. The method of making the nucleic acids and the fusion polypeptide ligands is broadly applicable to the production of polypeptide ligands in general, resulting in improved affinity and/or increased activity of the ligand when compared to its native form.
REFERENCES:
patent: 5521073 (1996-05-01), Davis et al.
patent: 5580757 (1996-12-01), Desnick et al.
patent: 5643755 (1997-07-01), Davis et al.
patent: 5650490 (1997-07-01), Davis et al.
patent: 5747033 (1998-05-01), Davis et al.
patent: 5814478 (1998-09-01), Valenzuela et al.
patent: 5851797 (1998-12-01), Valenzuela et al.
patent: 5879672 (1999-03-01), Davis et al.
patent: 6265564 (2001-07-01), Davis et al.
patent: 6337387 (2002-01-01), Sakano et al.
patent: 0816510 (1998-01-01), None
patent: WO 92/03569 (1992-03-01), None
patent: WO 94/11020 (1994-05-01), None
patent: WO 95/27060 (1995-10-01), None
patent: WO 96/11269 (1996-04-01), None
patent: WO 96/31598 (1996-10-01), None
patent: WO 96/37621 (1996-11-01), None
patent: WO 97/15667 (1997-05-01), None
patent: WO 97/48804 (1997-12-01), None
patent: WO 98/05779 (1998-02-01), None
ONCOGENE, vol. 9, 1994, Henkemeyer, et al., “Immunolocalization of the Nuk receptor tyrosine kinase suggests roles in segmental patterning of the brain and axonogenesis” pp. 1001-1014.
SCIENCE, vol. 266, Nov. 4, 1994, Davis, et al., “Ligands for EPH-Related Receptor Tyrosine Kinases That Require Membrane Attachment or Clustering for Activity”, pp. 816-819.
DNA Cell Biology, Aug. 1996 vol. 15, No. 8, Tournay C, et al., “Uptake of recombinant myeloperoxidase, free or fused to Fc-γ, by macrophages enhances killing activity towards micro-organisms”, pp. 617-624.
Molecular and Cellular Biology, Sep. 1995, Bergemann, et al., “ELF-2, a New Member of the Eph Ligand Family, Is Segmentally Expressed in Mouse Embryos in the Region of the Hindbrain and Newly Forming Somites”, pp. 4921-4929.
NEURON, vol. 17, Jul. 1996, Gale, et al., “Eph Receptors and Ligands Comprise Two Major Specificity Subclasses and Are Reciprocally Compartmentalized during Embryogenesis”, pp. 9-19.
CELL, vol. 87, Dec. 27, 1996, Davis, et al., “Isolation of Angiopoietin-1, a Ligand for the TIE2 Receptor, by Secretion-Trap Expression Cloning”, pp. 1161-1169.
CELL, vol. 90, 403-404, Aug. 8, 1997, Eph Nomenclature Committee, Letter to the Editor, “Unified Nomenclature for Eph Family Receptors and Their Ligands, the Ephrins”, pp. 403-404.
Cell & Tissue Research, vol. 290, 1997, Gale, et al., “Ephrins and their receptors: a repulsive topic?”, pp. 227-241.
SCIENCE, vol. 277, Jul. 4, 1997, Maisonpierre, et al., “Angiopoietin-2, a Natural Antagonist for Tie2 That Disrupts in vivo Angiogenesis”, pp. 55-60.
Davis Samuel
Gale Nicholas W.
Stahl Neil
Yancopoulos George D.
Gregg, Esq. Valeta
O'Hara Eileen B.
Regeneron Pharmaceuticals Inc.
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