Method of enhancing the biodistribution of antibody for localiza

Details Method of enhancing the biodistribution of antibody for localiza Method of enhancing the biodistribution of antibody for localiza

1988-04-12

1990-05-01

Maples, John S.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

424 9, 424 8591, 530402, A61K 4902, A61K 39395

Patent

active

049216902

ABSTRACT:
A method for enhancing the biodistribution of antibody for localization in lesions comprising initially exposing a mammalian subject containing lesion-associated marker substance to a first antibody specific for a given epitope of the marker substance, and after a period of time such that the marker substance has associated with the antibody, exposing the mammal to a further amount of the same antibody, or a second antibody specific either for an epitope of the marker substance different from the epitope for which the first antibody is specific, or for the same epitope of the marker substance as the first antibody but of a different binding affinity from the first antibody.

REFERENCES:
patent: 4565687 (1986-01-01), Khazaeli et al.
patent: 4624846 (1986-11-01), Goldenberg
patent: 4665897 (1987-05-01), Lemelson

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