Method of enhancing the attachment of endothelial cells on a mat

Details Method of enhancing the attachment of endothelial cells on a mat Method of enhancing the attachment of endothelial cells on a mat

1982-11-17

1990-10-02

Apley, Richard J.

Prosthesis (i.e., artificial body members), parts thereof, or ai

Arterial prosthesis

Stent structure

623 11, 623 15, A61F 206, A61F 202

Patent

active

049604236

ABSTRACT:
The attachment and growth of endothelial cells on the luminal surface of a vascular prosthesis are enhanced by coating the luminal surface of the vascular prosthesis with peptide derived from elastin. The resultant vascular prosthesis, which may be seeded with endothelial cells just prior to implantation has an enhanced anti-thrombogenic luminal surface.

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Postlewaite et al., Proc. Natl. Acad. Sci USA, 75, 871 (1978).
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Seppa et al., Cell. Biology, 5, 813 (1981).
Ali et al., Cell, 14 439 (1978).
Partridge; "The Chemistry of Connective Tissues", J. of Biochemistry, 61, 11 (1955).

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