Method of enhancing the administration of pharmalogically active

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...

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A61K 4700

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active

040739430

ABSTRACT:
According to the method of the invention, the parenteral administration of water-insoluble pharmacologically active agents is enhanced wherein the agents are administered in the lipoid phase of a carrier emulsion comprising a microemulsion of a finely dispersed lipoid in an aqueous phase. The lipoid preferably has a mean particle size below 1 micron. This makes it possible to administer water-insoluble agents in high concentrations, and thus a lower dose, whereby a rapid onset of the pharmacological effect is accompanied by a markedly reduced incidence of injury to body tissues.

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patent: 2972565 (1961-02-01), Zilversmit
patent: 2988484 (1961-06-01), Barsky
patent: 3089823 (1963-05-01), Czarnecki
patent: 3169094 (1965-02-01), Wretlind
patent: 3216897 (1965-11-01), Krantz et al.
patent: 3240670 (1966-03-01), Feinberg
patent: 3384545 (1968-05-01), Aiello et al.
Remington's Pharmaceutical Sciences (1965), p. 288.

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