Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai
Patent
1996-08-16
1998-12-22
Fitzgerald, David L.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Peptide containing doai
435 2, 424 851, A61K 3818
Patent
active
058519840
ABSTRACT:
Uses for Wnt polypeptides in hematopoiesis are disclosed. In particular, in vitro and in vivo methods for enhancing proliferation or differentiation of a hematopoietic stem/progenitor cell using a Wnt polypeptide, and optionally another cytokine, are described.
REFERENCES:
patent: Re30985 (1982-06-01), Cartaya
patent: 3691016 (1972-09-01), Patel
patent: 3773919 (1973-11-01), Boswell
patent: 3969287 (1976-07-01), Jaworek et al.
patent: 4002531 (1977-01-01), Royer
patent: 4179337 (1979-12-01), Davis et al.
patent: 4195128 (1980-03-01), Hildebrand et al.
patent: 4229537 (1980-10-01), Hodgins et al.
patent: 4247642 (1981-01-01), Hirohara et al.
patent: 4275149 (1981-06-01), Litman et al.
patent: 4301144 (1981-11-01), Iwashita et al.
patent: 4330440 (1982-05-01), Ayers et al.
patent: 4376110 (1983-03-01), David et al.
patent: 4377513 (1983-03-01), Sugimoto et al.
patent: 4399216 (1983-08-01), Axel et al.
patent: 4419446 (1983-12-01), Howley et al.
patent: 4485045 (1984-11-01), Regen
patent: 4496689 (1985-01-01), Mitra
patent: 4544545 (1985-10-01), Ryan et al.
patent: 4560655 (1985-12-01), Baker
patent: 4601978 (1986-07-01), Karin
patent: 4640835 (1987-02-01), Shimizu et al.
patent: 4657866 (1987-04-01), Kumar
patent: 4670417 (1987-06-01), Iwasaki et al.
patent: 4676980 (1987-06-01), Segal et al.
patent: 4767704 (1988-08-01), Cleveland et al.
patent: 4791192 (1988-12-01), Nakagawa et al.
patent: 4816567 (1989-03-01), Cabilly et al.
patent: 4927762 (1990-05-01), Darfler
patent: 4943529 (1990-07-01), Van den Berg et al.
patent: 4946783 (1990-08-01), Beckwith et al.
patent: 4965199 (1990-10-01), Capon et al.
patent: 5010182 (1991-04-01), Brake et al.
patent: 5013556 (1991-05-01), Woodle et al.
patent: 5122469 (1992-06-01), Mather et al.
patent: 5364934 (1994-11-01), Drayna et al.
Tissue Culture, Kruse and Patterson, eds., Academic Press (1973).
Al-Mashikhi et al., "Separation of immunoglobulin and transferrin from Blood serum and plasma by metal chelate interaction chromatography" J. Dairy Sci. 71:1756-1763 (1988).
Anderson et al., "Molecular cloning of mast cell growth factor, a hematopoietin that is active in both membrane bound and soluble forms" Cell 63:235-243 (1990).
Anderson, W.F., "Human gene therapy" Science 256:808-813 (1992).
Aplin et al., "Preparation, Properties, and Applications of Carbohydrate Conjugates of Proteins and Lipids" CRC Crit. Rev. Biochem. 10(4):259-306 (1981).
Aruffo et al., "CD44 is the Principal Cell Surface Receptor for Hyaluronate" Cell 61:1303-1313 (Jun. 29, 1990).
Ashkenazi et al., "Protection Against Endotoxic Shock by a Tumor Necrosis Factor Receptor Immunoadhesion" Proc. Natl. Acad. Sci. 88:10535-10539 (1991).
Baker, N., "Embryonic and imaginal requirements for wingless, a segment-polarity gene in Drosophila" Dev. Biol. 125:96-108 (1988).
Ballance et al., "Transformation of Aspergillus nidulans by the orotidine-5'-phosphate decarboxylase gene of Neurospora crassa" Biochem. & Biophys. Res. Comm. 112:284-289 (1983).
Banerji et al., "A Lymphocyte-specific Cellular Enhancer Is Located Downstream of the Joining Region in Immunoglobulin Heavy Chain Genes"Cell 33:729-740 (Jul. 1983).
Barnes et al., "Methods for Growth of Cultured Cells in Serum-free Medium" Analytical Biochemistry 102:255-270 (1980).
Bayer et al., "The avidin-biotin complex in affinity cytochemistry" Methods in Enzymology 62:308-315 (1979).
Beach et al., "High-Frequency Transformation of the Fission Yeast Schizosaccharomyces Pombe" Nature 290(12):140-142 (1981).
Beauchamp et al., "A new procedure for the synthesis of polyethylene glycol-protein adducts; effects on function, receptor recognition, and clearance fo superoxide dismutase, lactoferrin, and alpha 2-macroglobulin" Analytical Biochemistry 131(1):25-33 (1983).
Bennett et al., "Extracellular Domain-IgG Fusion Proteins for Three Human Natriuretic Peptide Receptors. Hormone Pharmacology and Application to Solid Phase Screening of Synthetic Peptide Antisera" The Journal of Biological Chemistry 266(34):23060-23067 (Dec. 5, 1991).
Bianchi et al., "Transformation of the yeast Kluyveromyces lactis by New Vectors Derived from the 1.6 .mu. Circular Plasmid pKD1" Curr. Genet. 12:185-192 (1987).
Bodine et al., "Effects of hematopoietic growth factors on the survival of primitive stem cells in liquid suspension culture" Blood 78:914-920 (1991).
Boggs et al., "Hematopoietic stem cells with high proliferative potential. Assay of their concentration in marrow by the frequency and duration of cure of W/Wv mice" J. Clin. Inv. 70(2):242-253 (1982).
Bradbury et al., "Wnt-4 expression induces a pregnancylike growth pattern in reconstituted mammary glands in virgin mice" Dev. Biol. 170:553-563 (1995).
Bradley and Brown, "The proto-oncogene int-1 encodes a secreted protein associated with the extracellular matrix" EMBO Journal 9:1569-1575 (1990).
Bradley and Brown, "A Soluble Form of Wnt-1 Protein with Mitogenic Activity on Mammary Epithelial Cells" Mole. Cell. Biol. 15(8):4616-4622 (1995).
Brodeur et al., "Mouse-Human Myeloma Partners for the Production of Heterohybridomas" Monoclonal Antibody Production Techniques and Applications, New York:Marcel Dekker, Inc. pp. 51-63 (1987).
Bruggemann et al., "Designer Mice: The Production of Human Antibody Repertoires in Transgenic Animals" Year in Immunology 7:33-40 (1993).
Byrn et al., "Biological Properties of a CD4 Immunoadhesin" Nature 344:667-670 (Apr. 12, 1990).
Canaani et al., "Regulated Expression of Human Interferon .beta..sub.1 Gene After Transduction into Cultured Mouse and Rabbit Cells" Proc. Natl. Acad. Sci. USA 79:5166-5170 (Sep. 1982).
Capon et al., "Designing CD4 Immunoadhesins for AIDS Therapy" Nature 337:525-531 (Feb. 9, 1989).
Carter et al., "Humanization of an anti-p185.sup.HER2 antibody for human cancer therapy" Proc. Natl. Acad. Sci. 89:4285-4289 (1992).
Case et al., "Efficient transformation of Neurospora crassa by utilizing hybrid plasmid DNA" Proc. Natl. Acad. Sci. 76:5259-5263 (1979).
Chang et al., "Phenotypic Expression in E. coli of a DNA Sequence Coding for Mouse Dihydrofolate Reductase" Nature 275:617-624 (1978).
Chothia and Lesk, "Canonical structures for the hypervariable regions of immunoglobulins" J. Mol. Biol. 196(4):901-917 (1987).
Christian and Moon, "Interactions between Xwnt-8 and Spemann organizer signaling pathways generate dorsoventral pattern in the embryonic mesoderm of Xenopus" Genes Dev. 7:13-28 (1993).
Christian and Moon, "When cells take fate into their own hands: differential competence to respond to inducing signals generates diversity in the embryonic mesoderm" Bio Essays 15(2):135-140 (1993).
Christiansen et al., "Murine Wnt-11 and Wnt-12 have temporally and spatially restricted expression patterns during embryonic development" Mech. Dev. 51(2-3):341-350 (1995).
Clackson et al., "Making antibody fragments using phage display libraries" Nature 352:624-628 (1991).
Cooke, J., "Induction and All That" Nature 358:111-112 (1992).
Creighton, T.E. Proteins: Structure and Molecular Properties, W.H. Freeman & Co.: San Francisco pp. 79-86 (1983).
David et al., "Protein Iodination and Solid State Lactoperoxidase" Biochemistry 13(5):1014-1021 (1974).
deBoer et al., "The TAC Promoter: A functional Hybrid Derived From the TRP and LAC Promoters" Proc. Natl. Acad. Sci. USA 80:21-25 (1983).
Depicker et al., "Nopaline Synthase: Transcript Mapping and DNA Sequence" J. Mol. Appl. Gen. 1:561-573 (1982).
Dexter et al., "Growth and Differentiation in the Hemopoietic System" Ann. Rev. Cell. Biol. 3:423-441 (1987).
Duksin et al., "Relationship of the Structure and Biological Activity of the Natural Homologues of Tunicamycin" Journal of Biological Chemistry 257:3105-3109 (1982).
Dzau et al., "Gene therapy for cardiovascular disease" Trends in Biochemistry 11:205-210 (1993).
Dzierzak and Medvinsky, "Mouse embryonic hematopoiesis" Trends Genet. 11:359-366 (1995).
Edge et al., "Deglycosylation of glycoproteins by trifluoromethane-sulfonic acid" Analytical Biochemistry 118:131-137 (1981).
Eppstein et al., "Biological Activity of Liposome-Encapsulated Murine Interferon Gamma Is Mediated by a C
Austin Timothy W.
Matthews William
Basham Daryl A.
Fitzgerald David L.
Genentech Inc.
Marschang Diane L.
Svoboda Craig G.
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