Chemistry: natural resins or derivatives; peptides or proteins; – Peptides of 3 to 100 amino acid residues – Chemical aftertreatment – e.g. – acylation – methylation – etc.
Patent
1989-01-18
1991-06-04
Doll, John
Chemistry: natural resins or derivatives; peptides or proteins;
Peptides of 3 to 100 amino acid residues
Chemical aftertreatment, e.g., acylation, methylation, etc.
530359, 530806, 530853, A61K 3702, C07K 100
Patent
active
050215515
ABSTRACT:
A method is disclosed for enhancement of the immunogenicity of a T cell immunogenic peptide which comprises adding an acidic amino acid at the N-terminus and/or a positive charge at the C-terminus of said peptide.
REFERENCES:
R. B. Merrifield, "Angewandte Chemie", vol. 97 (1985), p. 801-812.
Morrison and Boyd, 3rd Ed., "Organic Chemistry", Allyn and Bacon (1979) p. 603.
James T. Barrett, "Textbook of Immunology", C. V. Mosby Co. (1978) 3rd Ed. pp. 70-79.
Allen Paul M.
Unanue Emil R.
Celsa Rennett M.
Doll John
Meyer Scott J.
Washington University
Williams, Jr. James W.
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