Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Hormone or other secreted growth regulatory factor,...
Reexamination Certificate
2008-05-06
2008-05-06
Rao, Manjunath (Department: 1647)
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Hormone or other secreted growth regulatory factor,...
C435S365000, C435S368000, C435S377000, C514S012200, C530S399000
Reexamination Certificate
active
10630967
ABSTRACT:
The present invention relates to a method of increasing the number and/or differentiation of neural stem cells and/or neural stem cell progeny using pituitary adenylate cyclase-activating polypetide (PACAP). In a preferred embodiment, additional growth factors are also utilized. The present invention can be practiced in vivo and in vitro, rendering it useful for the treatment of neurodegenerative disease and other neural trauma.
REFERENCES:
patent: 4767628 (1988-08-01), Hutchinson
patent: 5023252 (1991-06-01), Hseih
patent: 5128242 (1992-07-01), Arimura et al.
patent: 5198542 (1993-03-01), Onda et al.
patent: 5208320 (1993-05-01), Kitada et al.
patent: 5231178 (1993-07-01), Holtz et al.
patent: 5268164 (1993-12-01), Kozarich
patent: 5326860 (1994-07-01), Onda et al.
patent: 5473054 (1995-12-01), Jameson
patent: 5506107 (1996-04-01), Cunningham
patent: 5506206 (1996-04-01), Kozarich
patent: 5521069 (1996-05-01), Onda et al.
patent: 5527527 (1996-06-01), Friden
patent: 5547935 (1996-08-01), Mullenbach et al.
patent: 5559143 (1996-09-01), McDonald
patent: 5614184 (1997-03-01), Sytkowski et al.
patent: 5623050 (1997-04-01), Kitada et al.
patent: 5686416 (1997-11-01), Kozarich
patent: 5723115 (1998-03-01), Serrero
patent: 5750376 (1998-05-01), Weiss et al.
patent: 5753506 (1998-05-01), Johe
patent: 5773569 (1998-06-01), Wrighton et al.
patent: 5801147 (1998-09-01), Kitada et al.
patent: 5833988 (1998-11-01), Friden
patent: 5837460 (1998-11-01), Von Feldt et al.
patent: 5851832 (1998-12-01), Weiss et al.
patent: 5877169 (1999-03-01), Simpkins
patent: 5885574 (1999-03-01), Elliott
patent: 5955346 (1999-09-01), Wells et al.
patent: 5977307 (1999-11-01), Friden et al.
patent: 5980885 (1999-11-01), Weiss et al.
patent: 6015555 (2000-01-01), Friden
patent: 6017533 (2000-01-01), Moro et al.
patent: 6048971 (2000-04-01), Sytkowski et al.
patent: 6165783 (2000-12-01), Weiss et al.
patent: 6191106 (2001-02-01), Mullenbach et al.
patent: 6239105 (2001-05-01), Brewitt
patent: 6242563 (2001-06-01), Dong
patent: 6294346 (2001-09-01), Weiss et al.
patent: 6329508 (2001-12-01), Friden
patent: 6333031 (2001-12-01), Olsson et al.
patent: 6399316 (2002-06-01), Onda et al.
patent: 6413952 (2002-07-01), Luengo et al.
patent: 6429186 (2002-08-01), Fuh et al.
patent: 6551618 (2003-04-01), Baird et al.
patent: 6680295 (2004-01-01), Arimura
patent: 6797264 (2004-09-01), Eriksson
patent: 7048934 (2006-05-01), Thompson et al.
patent: 2002/0098178 (2002-07-01), Brand
patent: 2003/0049838 (2003-03-01), Thompson et al.
patent: 2003/0054551 (2003-03-01), Shingo et al.
patent: 2003/0054998 (2003-03-01), Shingo et al.
patent: 2004/0038888 (2004-02-01), Mercer et al.
patent: 2006/0121007 (2006-06-01), Thompson et al.
patent: 2006/0148084 (2006-07-01), Shingo et al.
patent: 2007/0098698 (2007-05-01), Gregg et al.
patent: 2007/0179092 (2007-08-01), Ohta et al.
patent: 0 456 279 (1992-01-01), None
patent: 0 467 279 (1992-01-01), None
patent: WO 90 05185 (1990-05-01), None
patent: WO93/01275 (1993-01-01), None
patent: WO 96 40231 (1993-01-01), None
patent: WO 00 13650 (1994-04-01), None
patent: WO94/10292 (1994-05-01), None
patent: WO 97 48729 (1994-05-01), None
patent: WO 99 15191 (1996-03-01), None
patent: WO9609318 (1996-03-01), None
patent: WO 99 21966 (1999-05-01), None
patent: WO 99 51272 (1999-10-01), None
patent: WO 00 05260 (2000-02-01), None
patent: WO 00 30675 (2000-06-01), None
patent: WO 200030675 (2000-06-01), None
patent: WO 03/018782 (2003-03-01), None
patent: WO 03 24472 (2003-03-01), None
patent: WO 03/040310 (2003-05-01), None
patent: WO 03 92716 (2003-11-01), None
Whittemore et al., Exp Cell Res. Oct. 10, 1999;252(1):75-95.
Schlessinger et al., Molecular Cell. Sep. 2000;6(3):743-50.
Hirose, M. et al., “Gene expression of PACAP and its receptors in the ES cell-derived neuronal stem cells.” Japanese Journal of Pharmacology, The Japanese Pharmacological Society, Kyoto, JP, vol. 88, No. suppl. 1, p. 143.
Lelievre, V. et al., “Fibroblast growth factor-2 converts PACAP growth action on embryonic hindbrain precursors from stimulation to inhibition.” Journal of Neuroscience Research, vol. 67, No. 5, Mar. 1, 2002, pp. 566-573.
Lelievre, V. et al., “Cross-talk between PACAP and sonic hedgehog (SHH) pathways in neural stem cells, cerebellar granular progenitor cells and oligodendrocyte progenitors to control cell fate and proliferation.” Regulatory Peptides, vol. 115, No. 1, 2003, p. 50.
Lelievre, V. et al., “Interactive of PACAP with sonic Hedgehog on neural stem cell and oligodendrocyte progenitor proliferation.” Journal of Neurochemistry, vol. 85, No. Supplement 1, May 20, 2003, p. 66.
Ohta et al., “Pituitary adenylate cyclase-activating polypeptide (PACAP) regulates forebrain neural stem cell fate in vitro and in vivo,” Society for Neuroscience Abstract Viewer and Itinerary Planner, vol. 2002, page abstract No. 329.13, 2002.
Pesce, Mauricio et al., “Pituitary adenylate cyclass-activating polypeptide (PACAP) stimulates adenylate cyclase and promotes proliferation of mouse primordial germ cells.” Development (Cambridge), vol. 122, No. 1, 1996, pp. 215-221.
Rostene, W. et al., “VIP and PAGAP via G-Protien coupled receptors are potent inducers of mouse embryonic stem cell neuronal differentiation.” Regulatory Peptides, vol. 115, No. 1, 2003, p. 55.
Vaudry, David et al., “Neurotrophic activity of pituitary adenylate cyclase-activating polypeptide on rate cerebellar cortex during development.” Proceeding of the National Academy of Sciences of the United States, vol. 96, No. 16, Aug. 3, 1999, pp. 9415-9420.
A. Arimura, “Pituitary Adenylate Cyclase Activating Polypeptide (PACAP):Discovery and Current Status of Research”, Regulatory Peptides, 37:287-303 (1992). Elsevier Science Publishers.
A. Arimura et al., “Perspectives on Pituitary Adenylate Cyclase Activating Polypeptide (PACAP) in the Neuroendocrine, Endocrine, and Nervous Systems”, Jap. J. Physiol. 48:301-331 (1998). Center for Academic Publications, Japan.
A. Arimura et al., “Tissue Distribution of PACAP as Determined by RIA: Highly Abundant in the Rat Brain Testes”, Endocrinol. 129:2787-2789 (1991). Williams & Wilkins.
A. Arimura et al., “PACAP Functions as a Neurotrophic Factor”, Ann. N.Y. Acad. Sci. 739:228-243 (1994), New York Academy of Science, New York.
W.A. Banks et al., “Passage of Pituitary Adenylate Cyclase Activating Polypeptide 1-27 and Pituitary Adenylate Cyclase . . . ”, J. Pharmacol. Exp. Ther. 267(2):690-6 (1993). William & Wilkins.
S.A. Bayer, “Neuron Production in the Hippocampus and Olfactory Bulb of the Adult Rat Brain: Addition or Replacement?”, N.Y. Acad. Sci. 457:163-173 (1985). New York Academy of Sciences, New York.
S. Bernichtein et al., “S179D-human PRL, a Pseudeophosphorylated Human PRL Analog, is an Agonist and not an Antagonist”, Endocrinology 142(9):3950-3963 (2001). The Endocrine Society.
R.G. Carey et al., “Pituitary Adenylate Cyclase Activating Polypeptide Antimitogenic Signaling in Cerebral Cortical Progenitors is Regulated by p57Kip2-dependent CDK2 activity,” J. Neurosci. 22(5):1583-91 (2002). Society for Neuroscience.
J. Christophe, “Type I Receptors for PACAP (a neuropeptide even more important than VIP?)” Biochim. Biophys. Acta 1154:183-99 (1993). Elsevier Science Publishers.
C.G. Craig et al., “In vivio Growth Factor Expansion of Endogenous Subependymal Neural Precursor Cell Populations in Adult Mouse Brain,” J. Neurosci. 16(8):2649-58 (1996) Society for Neuroscience.
C.R. Freed et al., “Survival of Implanted Fetal Dopamine Cells and Neurologic Improvement 12 to 46 Months After Transplantation for Parkinson's Disease”, N. Engl. J. Med. 327:1549-1555 (1992).
D.E. Hansel et al., “Regulation of Olfactory Neurogenesis by Amidated Neuropeptides,”, J. Neurosci. Res. 66:1-7 (2001). Wiley-Liss.
H. Hashimoto et al., “Altered Psychomot
Ohta Shigeki
Weiss Samuel
Gamett Daniel C
Rao Manjunath
Stem Cell Therapeutics Inc.
LandOfFree
Method of enhancing neural stem cell proliferation,... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of enhancing neural stem cell proliferation,..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of enhancing neural stem cell proliferation,... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-3958654