Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1993-04-05
1997-08-12
Stanton, Brian R.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
435 691, 4351723, 435 692, 514 2, 514 8, 514629, 536 231, 935 34, 935 52, 935 55, A01N 3718, A01N 4304, A61K 3116, C12N 1509
Patent
active
056566093
ABSTRACT:
The expression of polynucleotide introduced into a cell by means of a targeted complex of the polynucleotide linked to a cell-specific binding agent can be enhanced and prolonged by inhibiting translocation or fusion of endosomes to lysosomes using colchicine.
REFERENCES:
patent: 5166320 (1992-11-01), Wu et al.
patent: 5354844 (1994-10-01), Beug et al.
Furlanetto, "Receptor-Mediated Endocytosis and Lysosomal Processing of Insulin-Like Growth Factor I by Mitogenically Responsive Cells" Endocrinology, vol. 122, No. 5, pp. 2044-2053, May 1988.
Stryer, Biochemistry, Third Edition, 1988, W.H. Freeman and Company, New York, USA, pp. 944-946.
Curiel et al. "Adenovirus enhancement of transferrin-polylysine-mediated gene delivery" PNAS 1991, vol. 88, pp. 8850-8854.
Wu et al. "Receptor-mediated Gene Delivery and Expression in Vivo" Journal of Biological Chemistry 1988, vol. 263, No. 29, pp. 14621-14624.
Zenke et al. "Receptor-mediated endocytosis of transferrin-polycation conjugates: An efficient way to introduce DNA into hematopoietic cells" PNAS 1990, vol. 87, pp. 3655-3659.
Cristiano et al. "Hepatic gene theraphy: Adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocycles" PNAS 1993, vol. 90, pp. 2122-2126.
Wu et al. 1989. J. Biol. Chem. 264(29):16985-16987.
Wu et al. Biotherapy 3(1):87-95.
Kaufman et al. 1990 Am J. Physiol. 258(1 pt 1) pp. G129-G137.
Wu Catherine H.
Wu George Y.
Stanton Brian R.
University of Connecticut
LandOfFree
Method of enhancing and/or prolonging expression of gene introdu does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of enhancing and/or prolonging expression of gene introdu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of enhancing and/or prolonging expression of gene introdu will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-160610