Method of enhancing and/or prolonging expression of gene introdu

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

435 691, 4351723, 435 692, 514 2, 514 8, 514629, 536 231, 935 34, 935 52, 935 55, A01N 3718, A01N 4304, A61K 3116, C12N 1509

Patent

active

056566093

ABSTRACT:
The expression of polynucleotide introduced into a cell by means of a targeted complex of the polynucleotide linked to a cell-specific binding agent can be enhanced and prolonged by inhibiting translocation or fusion of endosomes to lysosomes using colchicine.

REFERENCES:
patent: 5166320 (1992-11-01), Wu et al.
patent: 5354844 (1994-10-01), Beug et al.
Furlanetto, "Receptor-Mediated Endocytosis and Lysosomal Processing of Insulin-Like Growth Factor I by Mitogenically Responsive Cells" Endocrinology, vol. 122, No. 5, pp. 2044-2053, May 1988.
Stryer, Biochemistry, Third Edition, 1988, W.H. Freeman and Company, New York, USA, pp. 944-946.
Curiel et al. "Adenovirus enhancement of transferrin-polylysine-mediated gene delivery" PNAS 1991, vol. 88, pp. 8850-8854.
Wu et al. "Receptor-mediated Gene Delivery and Expression in Vivo" Journal of Biological Chemistry 1988, vol. 263, No. 29, pp. 14621-14624.
Zenke et al. "Receptor-mediated endocytosis of transferrin-polycation conjugates: An efficient way to introduce DNA into hematopoietic cells" PNAS 1990, vol. 87, pp. 3655-3659.
Cristiano et al. "Hepatic gene theraphy: Adenovirus enhancement of receptor-mediated gene delivery and expression in primary hepatocycles" PNAS 1993, vol. 90, pp. 2122-2126.
Wu et al. 1989. J. Biol. Chem. 264(29):16985-16987.
Wu et al. Biotherapy 3(1):87-95.
Kaufman et al. 1990 Am J. Physiol. 258(1 pt 1) pp. G129-G137.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Method of enhancing and/or prolonging expression of gene introdu does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of enhancing and/or prolonging expression of gene introdu, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of enhancing and/or prolonging expression of gene introdu will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-160610

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.