Method of enchancing t-PA and SCU-PA production

Details Method of enchancing t-PA and SCU-PA production Method of enchancing t-PA and SCU-PA production

1986-09-17

1989-12-26

Draper, Garnette D.

Chemistry: molecular biology and microbiology

Spore forming or isolating process

4352402, 43524021, 43524025, 435244, 435215, 435212, 435226, 435 694, 435183, 435216, 435948, 424 941, 424 9463, 424 9464, 514 8, 514 21, 514 56, C12N 502, C12N 972, A61K 3764

Patent

active

048898082

ABSTRACT:
Disclosed herein is a method of enhancing the production of tissue plasminogen activator (t-PA) and single chain urokinase plasminogen activator (SCU-PA) by normal human lung diploid fibroblast cells in a serum-free medium. The method comprises the addition of heparin (or low molecular weight heparin) and an endothelial cell growth factor to the culture medium.

REFERENCES:
patent: 4505893 (1985-03-01), Mori et al.
patent: 4520107 (1985-05-01), Healy et al.
patent: 4661453 (1987-04-01), Pollard
patent: 4752603 (1988-06-01), Collen et al.
patent: 4757005 (1988-07-01), Chen
patent: 4798796 (1989-01-01), Wilson
Schreiber et al., PNAS, vol. 82, 1985, pp. 6138-6142.
Kadouri et al., Advances in Biotechnological Processes, vol. 5, 1985, pp. 275-99.
Rappaport et al., Throm. Haemostasis, 59(3), pp. 514-22, 1988, vol. 86 of Biological Abstracts #72977.
Chen et al., J. Immunol., 132(6), 1984, p. 2955.
Vairel et al., Thrombosis Res. 30, 1983, pp. 219-224.
Paques et al., CA vol. 105, 1986, #543356.
Hamilton et al., Biochem Biophys. Res. Comm. 122(1), 1984, pp. 230-36.
Davies et al., Science 221, 1983, pp. 171-73.

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