Chemistry: molecular biology and microbiology – Carrier-bound or immobilized enzyme or microbial cell;... – Enzyme or microbial cell is immobilized on or in an organic...
Patent
1992-02-26
1994-02-08
Naff, David M.
Chemistry: molecular biology and microbiology
Carrier-bound or immobilized enzyme or microbial cell;...
Enzyme or microbial cell is immobilized on or in an organic...
425382R, 435179, 435180, 43524022, C12N 1104, C12N 500
Patent
active
052847616
ABSTRACT:
Methods and systems are disclosed for encapsulating viable cells which produce biologically-active factors. The cells are encapsulated within a semipermeable, polymeric membrane by co-extruding an aqueous cell suspension and a polymeric solution through a common port to form a tubular extrudate having a polymeric outer coating which encapsulates the cell suspension. For example, the cell suspension and the polymeric solution can be extruded through a common extrusion port having at least two concentric bores, such that the cell suspension is extruded through the inner bore and the polymeric solution is extruded through the outer bore. The polymeric solution coagulates to form an outer coating. As the outer coating is formed, the ends of the tubular extrudate can be sealed to form a cell capsule. In one embodiment, the tubular extrudate is sealed at intervals to define separate cell compartments connected by polymeric links.
REFERENCES:
patent: 3715277 (1973-02-01), Dinelli et al.
patent: 3947325 (1976-03-01), Dinelli et al.
patent: 3962383 (1976-06-01), Hagiwara et al.
patent: 4163691 (1979-08-01), Devos et al.
patent: 4251195 (1981-02-01), Suzuki et al.
patent: 4333906 (1982-06-01), Porter et al.
patent: 4426337 (1984-01-01), Suzuki et al.
patent: 4451253 (1984-05-01), Harman
patent: 4695466 (1987-09-01), Morishita et al.
patent: 4902450 (1990-02-01), Morrison
Tresco et al. (1992) Asaio Journal 38:17-23.
Aebischer et al. (1991) Science 242:133.
Winn et al. (1991) Experimental Neurology 113:322-329.
Aebischer et al. (1991) Brain Research 560:43-49.
Aebischer et al. (1991) J. Biomec. Engineering 113:178-183.
Aebischer et al. (1991) Experimental Neurology 111:269-275.
Aebischer et al. (1991) Biomaterials 12:50-56.
Jaeger et al. (1991) Brain Research 551:163-170.
Hoffman et al. (1990) Experimental Neurology 110:39-44.
Winn et al. (1989) Experimental Neurology 105:244-250.
Winn et al. (1989) J. Biomed. Mater. Res. 23:31-44.
Aebischer et al. (1988) Brain Research 448:364-368.
Jaeger et al. (1990) Progress in Brain Research 82:41-46.
Sugamori, et al., Trans. Am. Soc. Artif. Intern. Organs. vol. XXXV 1989, pp. 791-799.
Sefton, et al., Biotechnology and Bioengineering, vol. XXIX, 1987, pp. 1135-1143.
Aebischer Patrick
Wahlberg Lars
Brown University Research Foundation
Engellenner Thomas J.
Naff David M.
Vincent Matthew P.
LandOfFree
Method of encapsulating cells in a tubular extrudate does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of encapsulating cells in a tubular extrudate, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of encapsulating cells in a tubular extrudate will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-697216