Method of encapsulating biologically active materials in multila

Details Method of encapsulating biologically active materials in multila Method of encapsulating biologically active materials in multila

1982-10-04

1984-11-27

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

424 38, 424182, 424 11, 4284022, 436829, A61K 950, B01J 1302

Patent

active

044850549

ABSTRACT:
This invention provides an improved procedure for producing large multilamellar lipid vesicles (MLV), which may be used to encapsulate a biologically active material, particularly lipophilic substances. According to this invention, a lipid film is formed on inert, solid contact masses within a vessel, by evaporating an organic solvent therefrom. Subsequent agitation in the presence of an aqueous liquid, followed by a period in which the vessel remains undisturbed yields the multilamellar vesicles. The procedure permits the encapsulation of both hydrophilic and lipophilic materials.

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