Method of encapsulating biologically active materials in lipid v

Details Method of encapsulating biologically active materials in lipid v Method of encapsulating biologically active materials in lipid v

1978-11-30

1980-12-23

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 38, A01N 2526, A61K 922, A01N 2500

Patent

active

042410460

ABSTRACT:
The disclosure is of a method for encapsulating biologically active materials in synthetic, oligolamellar lipid vesicles (liposomes). The method comprises providing a mixture of lipid in organic solvent and an aqueous mixture of the material for encapsulation, emulsifying the provided mixture, removing the organic solvent and suspending the resultant gel in water. The method of the invention is advantageous over prior art methods of encapsulating biologically active materials in that it provides a means for a relatively high capture efficiency of the material for encapsulation. The disclosure is also of intermediate compositions in the encapsulation method, the product vesicles, compositions including the product vesicles as an active ingredient and their use.

REFERENCES:
patent: 3937668 (1976-02-01), Zolle
patent: 4089801 (1978-05-01), Schneiber
Gregoriadis, New England Jour. of Med., vol. 295, No. 14 (1976), pp. 765-770.

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