Method of encapsulating biological substances in microspheres

Details Method of encapsulating biological substances in microspheres Method of encapsulating biological substances in microspheres

1995-08-14

1997-08-12

Lovering, Richard D.

Chemistry: molecular biology and microbiology

Carrier-bound or immobilized enzyme or microbial cell;...

Enzyme or microbial cell is immobilized on or in an organic...

264 47, 424424, 424425, 424497, 425 5, 427508, 514866, 514885, 514962, C12N 1104, C12N 1108, B01J 1318

Patent

active

056564694

ABSTRACT:
A method for encapsulating biological substances in biocompatible microcapsules is disclosed, the method comprising:
(a) maintaining a coating-forming liquid film sheet transverse to a vertical plane, said sheet comprising an organic polymerizable monomer liquid,
(b) causing droplets comprising biological substances in an aqueous medium to fall downwardly through said liquid film sheet to form microcapsules comprising cores of said droplets coated by said film,
(c) permitting said microcapsules to fall downwardly from said liquid film sheet, and
(d) polymerizing said liquid film coatings during descent of said microcapsules below said sheet to form a permeable polymer coating of a sufficient structural integrity so that said microcapsules are self-supporting.

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