Method of enantioselective cyclopropanation using chiral catalys

Details Method of enantioselective cyclopropanation using chiral catalys Method of enantioselective cyclopropanation using chiral catalys

1990-03-29

1992-12-29

Tsang, Cecilia

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

546 2, 548101, 548105, 548403, 548531, 548540, 548551, 549326, 556 45, 556 57, 556137, 556438, 556479, 560102, 560124, 502166, 502167, C07C 1304, C07D30793, C07F 1500, C07F 1900

Patent

active

051753111

ABSTRACT:
A chiral catalyst is disclosed together with methods of using it for enantioselective syntheses. The chiral catalyst includes a nucleus with two metal atoms that has four bridging ligands oriented radially to the axis of the nucleus. Each of these ligands includes two complexing atoms each complexed to one of the metal atoms. At least one of the bridging ligands includes a chiral center which is bonded to one of the complexing atoms. Preferably, all four of the bridging ligands include a chiral center bonded to one of the complexing atoms. The catalyst of the invention has been found to be useful in catalyzing carbenoid transformation reactions such as cyclopropanation.

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