Method of eliminating protective groups

Details Method of eliminating protective groups Method of eliminating protective groups

1988-06-10

1990-12-11

Gerstl, Robert

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

540350, C07D48704, C07D50104

Patent

active

049772562

ABSTRACT:
A method of deprotection which comprises reacting a compound having at least one of amino, hydroxyl, mercapto and carboxyl groups protected by a substituted or unsubstituted benzyloxycarbonyl group or by a substituted or unsubstituted benzyl group with zinc in a buffer, thereby splitting off the protective benzyloxycarbonyl or benzyl group.

REFERENCES:
patent: 4429128 (1984-01-01), Rosati
Suzuki, Peptide Chemistry, 1976, pp. 45-48 (1977).
Roeske, The Peptides, vol. 3, p. 117 (1981).

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