Method of down-regulating gene expression

Details Method of down-regulating gene expression Method of down-regulating gene expression

1994-10-25

1997-01-07

Rories, Charles C. P.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 245, 424 7815, 424 7838, 424601, 424713, A61K 3170, A61K 31795, C07H 2100

Patent

active

055917216

ABSTRACT:
Disclosed is a method of down-regulating the expression of a gene in an animal, wherein a pharmalogical formulation comprising an oligonucleotide complementary to the gene is orally administered to an animal. The oligonucleotide administered has non-phosphodiester internucleotide linkages and includes at least one 2'-substituted ribonucleotide, the oligonucleotide inhibiting the expression of a product of the gene, thereby down-regulating the expression of the gene.

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