Method of DNA vaccination

Details Method of DNA vaccination Method of DNA vaccination

2006-07-11

2006-07-11

Ketter, James (Department: 1636)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

Reexamination Certificate

active

07074770

ABSTRACT:
A method of vaccinating a mammal against a disease state, comprising administrating to said mammal, within an appropriate vector, a nucleotide sequence encoding an antigenic peptide associated with the disease state; additionally administering to said mammal a compound which enhances both humoral and cellular immune responses initiated by the antigenic peptide, the compound being selected from the list contained herein, wherein the compound is preferably Tucaresol or a physiologically acceptable salt or ester thereof, where appropriate.

REFERENCES:
patent: 5508310 (1996-04-01), Rhodes
patent: 5620896 (1997-04-01), Herrmann et al.
patent: 5630796 (1997-05-01), Bellhouse et al.
patent: WO 94/07479 (1994-04-01), None
patent: WO94/07479 (1994-04-01), None
patent: WO 95/20660 (1995-08-01), None
Rhodes J. et al.: “Therapeutic potentiation of the immune system by costimulatory Schiff-base-forming drugs see comments!.” NATURE, (Sep. 1995) 377 (6544) 71-5.
Rhodes J. et al.: “Covalent chemical events in immune induction: fundamental and therapeutic aspects” Immunology Today, vol. 17, No. 9, 1996, pp. 436-441.
Sasaki S. et al.: “Comparison of intranasal and intramuscular immunization against human immunodeficiency virus type 1 with a dna-monophosphoryl lipid A adjuvant vaccine” Infection and Immunity, vol. 66, No. 2, (Feb. 1998), pp. 823-826.
Sasaki S. et al.: “Adjuvant effect of Ubenimex on a DNA vaccine for HIV-1” Clinical and Experimental Immunology, vol. 111, (Jan. 1998), pp. 30-35.

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