Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Hydrolases
Patent
1995-04-28
1995-12-26
Knode, Marian C.
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Hydrolases
424 9464, 424 941, A61K 3848, A61K 3843
Patent
active
054785588
ABSTRACT:
A method of dissolving venous thrombi using a thrombolytic, parenterally administrable drug containing activated protein C is described. The drug can be free of serum amyloid P, thrombin activity, infectious agents and antibodies against protein C and activated protein C.
REFERENCES:
patent: 5084274 (1992-01-01), Griffin et al.
Schwarz, H. P. et al. "Advances in Applied Biotechnology Series", vol. 11, "Protein C and Related Anticoagulants" Chapter 5 (Bruley and Drohan eds.), The Portfolio Publishing Co. The Woodlands, Texas (1990), pp. 83-89.
O. Taby, J. Chabbat and M. Steinbuch, "Inhibition of Activated Protein C by Aprotinin and the Use of the Insolubilized Inhibitor for its Purification"; Thrombosis Research 59:27-35, 1990.
O. Kohler, C. Milstein, "Continuous cultures of fused cells secreting antibody of predefined specificity," Nature, vol. 256 (Aug. 7, 1975) pp. 495-497.
Hirahara et al., "Synergistic Effect of Antithrombin III, Activated Protein C and Heparin on the Inhibition of the Tissue Thromboplastin-Mediated Coagulation," Chem. Pharm. Bull. 37(3): 692-96 (1989).
Eibl Johann
Linnau Yendra
Philapitsch Anton
Schwarz Hans P.
Immuno AG
Knode Marian C.
Larson K.
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