Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid
Patent
1994-06-28
1997-09-09
Zitomer, Stephanie W.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving nucleic acid
435 691, 4353201, 935 77, 935 78, C12Q 168, C12N 1585, C12P 2102
Patent
active
056655436
ABSTRACT:
The present invention provides a method of transcriptionally modulating the expression of a gene-of-interest. The method comprises contacting a cell which is capable of expressing the gene with an amount of a molecule effective to transcriptionally modulate expression of the gene and thereby affect the level of the protein encoded by the gene which is expressed by the cell. Molecules useful in the practice of the invention are characterized as follows (a) do not naturally occur in the cell, (b) bind to DNA or RNA or bind to a protein through a domain of such protein which is not a ligand binding domain of a receptor which naturally occurs in the cell. Additionally, this invention provides a method for determining whether a molecule known to be a modulator of protein biosynthesis is capable of transcriptionally modulating expression of a gene-of-interest.
REFERENCES:
patent: 4535058 (1985-08-01), Weinberg et al.
patent: 4601978 (1986-07-01), Karin
patent: 4699877 (1987-10-01), Cline et al.
patent: 4736866 (1988-04-01), Leder et al.
patent: 4738922 (1988-04-01), Haseltine et al.
patent: 4740461 (1988-04-01), Kaufman
patent: 4740463 (1988-04-01), Weinberg et al.
patent: 4761367 (1988-08-01), Edgell et al.
patent: 4761371 (1988-08-01), Bell et al.
patent: 4806463 (1989-02-01), Goodchild et al.
patent: 4827079 (1989-05-01), Evans et al.
patent: 4861709 (1989-08-01), Ulitzer et al.
patent: 4885238 (1989-12-01), Reddel et al.
patent: 4935363 (1990-06-01), Brown et al.
patent: 4981783 (1991-01-01), Augenlicht
patent: 4981790 (1991-01-01), Haseltine et al.
patent: 5070012 (1991-12-01), Nolan et al.
patent: 5071773 (1991-12-01), Evans et al.
patent: 5075229 (1991-12-01), Hanson et al.
patent: 5262300 (1993-11-01), Evans et al.
Andersen, R. et al. (1990) "Metal-Dependent Binding of a Nuclear Factor to the Rat Metallothionein-I Promoter," Nucleic Acids Research 18 (20): 6049-6055.
Angel, P. et al., (1987 A) "Phorbol Ester-Inducible Genes Contain A Common Cis Element Recognized by An TPA-Modulated Trans-Acting Factor," Cell 49: 729-739.
Angel, P. et al., (1987 B) "12-O-Tetradecanoyl-Phorbol-13-Acetate Induction of the Human Collagenase Gene Is Mediated by an Inducible Enhancer Element Located in the 5'-Flanking Region," Molecular and Cellular Biology, 7: 2256-2266.
Bickel, M. et al., (1988) "Granulocyte-Macrophage Colony-Stimulating Factor Regulation in Murine T Cells and Its Relation to Cyclosporin A," Ex. Hematol. 16: 691-965.
Blumberg, P., (1988) "Protein Kinase C as the Receptor for the Phorbol Ester Tumor Promoters: Sixth Rhoads Memorial Award Lecture," Cancer Research 48: 1-8.
Brasier, A. et al., (1989) "Optimized Use of the Firefly Luciferase Assay as a Reporter Gene in Mammalian Cell Lines," BioTechniques 7 (10): 1116-1122.
Brenner C. et al., (1989) "Message Amplification Phenotyping (MAPPing): A Technique to Simultaneously Measure Multiple mRNAs from Small Numbers of Cells," BioTechniques 7 (10): 1096-1103.
Cao, T., (1989) "A Simple and Inexpensive System to Amplify DNA by PCR," BioTechniques 1 (6): 566-567.
Cohen, P. and Foulkes, J.G. eds., (1991) The Hormonal Control of Gene Transcription, 92-93, 235-236.
Comb, M. et al. (1986) "A Cyclic AMP-and Phorbol Ester-Inducible DNA Element," Nature 323: 353-356.
Connelly, C. et al., (1989) "The Role of Transgenic Animals in the Analysis of Various Biological Aspects of Normal and Pathologic States," Experimental Cell Research 183: 257-276.
Cybulsky, M. et al., (1991) "Gene Structure, Chromosomal Location, and Basis for Alternative mRNA Splicing of the Human VCAM1 Gene," Proc. Natl. Acad. Sci. USA 88: 7859-7863.
Das, H. et al., (1988) "Cell Type-Specific Expression of the Human ApoB Gene Is Controlled by Two Cis-Acting Regulatory Regions," Journal of Biological Chemistry 263 (23): 11452-11458.
de Wet et al., (1987) "Firefly Luciferase Gene: Structure and Expression in Mammalian Cells," Molecular and Cellular Biology 7 (2): 725-737.
Emmel, E. et al., (1989) "Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation," Science 246: 1617-1620.
Engebrecht, J. et al., (1985) "Measuring Gene Expression with Light," Science 227: 1345-1347.
Gunter, K. et al., (1989) "Cyclosporin A-Mediated Inhibition of Mitogen-Induced Gene Transcription Is Specific for the Mitogenic Stimulus and Cell Type," Journal of Immunology 142: 3286-3291.
Higuchi, K. et al., (1988) "Tissue-Specific Expression of Apolipoprotein A-I (ApoA-I) Is Regulated by the 5'-Flanking Region of the Human ApoA-I Gene," Journal of Biological Chemistry 263 (34): 18530-18536.
Holbrook, N. et al., (1984) "T-Cell Growth Factor: Complete Nucleotide Sequence and Organization of the Gene in Normal and Malignant Cells," Proc. Natl. Acad. Sci USA 81: 1634-1638.
Hsu, M. et al., (1991) "Inhibition of HIV Replication in Acute and Chronic Infections in Vitro by a Tat Antagonist," Science, 254: 1799-1802.
Ishii, S. et al., (1985) "Characterization and Sequence of the Promoter Region of the Human Epidermal Growth Factor Receptor Gene," Proc. Natl. Acad. Sci. USA 82: 4920-4924.
Kaushansky, K. et al., (1985) "Genomic Cloning, Characterization, Multilineage Growth-Promoting Activity of Human Granulocyte-Macrophage Colony-Stimulating Factor," Proc. Natl. Acad. Sci. USA 83:3101-3105.
Kawasaki, E. et al., (1985) "Molecular Cloning of a Complementary DNA Encoding Human Macrophage-Specific Colony-Stimulating Factor (CSF-1)," Science 230: 291-296.
Knott, T. et al., (1986) "Complete Protein Sequence and Identification of Structural Domains of Human Apolipoprotein B," Nature 323: 734-738.
Kronke, M. et al., (1984) "Cyclosporin A Inhibits T-Cell Growth Factor Gene Expression at the Level of mRNA Transcription," Proc. Natl. Acad. Sci. USA 81: 5214-5218.
Ladner, M. et al., (1987) "Human CSF-1: Gene Structure and Alternative splicing of mRNA Precursors," The EMBO Journal 6 (9): 2693-2698.
Lamb, P. et al., (1986) "Characterization of the Human p53 Gene," Molecular and Cellular Biology 6 (5): 1379-1385.
Lee, M-T. et al., (1990) "Differential Expression of M-CSF, G-CSF, and GM-CSF by Human Monocytes," Biol. Abstr. 89 (10): AB-100645.
Lefevre, C. et al., (1987) "Tissue-Specific Expression of the Human Growth Hormone Gene Is Conferred in Part by the Binding of a Specific Trans-Acting Factor," The EMBO Journal 6 (4): 971-981.
Lim, K. et al., (1989) "A Simple Assay for DNA Transfection by Incubation of the Cells in Culture Dishes with Substrates for Beta-Galactosidase," BioTechnique 7 (6): 576-579.
Lin, F. et al., (1985) "Cloning and Expression of the Human Erythropoietin Gene," Proc. Natl. Acad. Sci. USA 82: 7580-7584.
Majesky, M. et al., (1990) "PDGF Ligand and Receptor Gene Expression during Repair of Arterial Injury," Journal of Cell Biology 11: 2149-2158.
Maniatis, T. et al., (1987) "Regulation of Inducible and Tissue-Specific Gene Expression," Science 236: 1237-1245.
Mayo, K. et al., (1982) "Altered Regulation of the Mouse Metallothionein-I Gene Following Gene Amplification or Transfection," (in Gene Amplification) Schimke, R.T. ed., 67-73.
McCall, C. et al., (1989) "Biotherapy: A New Dimension in Cancer Treatment." Bioechnology 7: 231-240.
Metzler, D., (1977) Biochemistry: The Chemical Reactions of Living Cells, 116-117. Mun jaal, R. et al., (1989) "In Situ Detection of Progesterone Receptor mRNA in the Chicken Oviduct Using Probe-on Slides," BioTechniques 7 (10): 1104-1108.
Myoken, Y. et al., (1991) "Vascular Endothelial Growth Factor (VEGF) Produced by A-431 Human Epidermoid Carcinoma Cells and Identification of VEGF Membrane Binding Sites," Cell Biology 88: 5819-5823.
Nagata, S. et al., (1986) "The Chromosomal Gene Structure and Two mRNAs for Human Granulocyte Colony-Stimulating Factor," The EMBO Journal 5 (3): 575-581.
Nimer, S. et al., (1988) "Serum Cholesterol-Lowering Activity of Granulocyte-Macrophage Colony-Stimulating Factor," JAMA 260 (22): 3297-3300.
Nishizuka, Y., (1986) "Studies and Perspectives of Protein Kinase C," Science 233: 305-312.
Paul, W. (1984) Fundamental Immunology, 275-276.
Pons, M. et al., (1990) "A New Cellular Model of Response to Estrogens: A Biolumin
Foulkes J. Gordon
Franco Robert
Leichtfried Franz
Pieler Christian
Stephenson John R.
Oncogene Science, Inc.
White John P.
Zitomer Stephanie W.
LandOfFree
Method of discovering chemicals capable of functioning as gene e does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of discovering chemicals capable of functioning as gene e, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of discovering chemicals capable of functioning as gene e will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-68720