Drug – bio-affecting and body treating compositions – Whole live micro-organism – cell – or virus containing – Genetically modified micro-organism – cell – or virus
Reexamination Certificate
2005-11-30
2009-12-29
Stucker, Jeffrey (Department: 1649)
Drug, bio-affecting and body treating compositions
Whole live micro-organism, cell, or virus containing
Genetically modified micro-organism, cell, or virus
C424S570000, C435S320100, C435S325000, C435S368000, C435S007100, C536S023100
Reexamination Certificate
active
07638119
ABSTRACT:
A method of diminishing the symptoms of neurodegenerative disease in a patient is disclosed. In one embodiment, the method comprises the steps of: (a) identifying a patient with a neurodegenerative disease, (b) producing a cell culture, wherein the cell culture comprises cells with induced antioxidant response element (ARE) mediated transcription, and (c) transplanting at least a portion of the cell culture into the brain of the patient, wherein symptoms of neurodegenerative disease are diminished.
REFERENCES:
Ridet et al., J Neurosc Res 72: 704-708, 2003.
van Muiswinkel & Kuiperij, Curr. Drug Targets—CNS & Neurological Dis, 4: 267-281, 2005.
Beal and Ferrante, Nat Rev 5: 373-384, 2004.
Halliday et al Clin Exp Pharmacol Physiol 27: 1-8, 2000.
Steece-Collier et al., PNAS USA 99(22): 13972-13974, 2002.
Feigin et al., Curr Opin Neurol 15: 483-489, 2002.
Gaura et al., Brain 127: 65-72, 2003.
Lee et al., J Biol Chem 278: 12029-12038, 2003.
Dakshinamoorthy and Jaiswal Oncogene 20: 3906-3917, 2001.
Nguyen et al., Free Radical Biol and Med 37: 433-441, 2004.
Calkins et al. Huntington's Disease Advocacy Center Article-1 page.
Chicurel, M. HD Therapeutic pipeline, 2006.
Bossy-Wetzel E, et al., “Molecular pathways to neurodegeneration,” Nat. Med. 10: S2-9 (2004).
Calkins M, et al., “Protection from mitochondrial complex II inhibition in vitro and in vivo by Nrf2-mediated transcription,” Proc. Natl. Acad. Sci. USA 102:244-249 (2005).
DiMauro S, et al., “Mitochondrial abnormalities in muscle and other aging cells: classification, causes, and effects,” Muscle Nerve 26:597-607 (2002).
Emerit J, et al., “Neurodegenerative diseases and oxidative stress,” Biomed. Pharmacother. 58:39-46 (2004).
Manfredi G & Beal F, “The role of mitochondria in the pathogenesis of neurodegenerative diseases,” Brain Pathol. 10:462-472 (2000).
Schon E & Manfredi G, “Neuronal degeneration and mitochondrial dysfunction,” J. Clin. Invest. 111:303-312 (2003).
Svendsen C & Langston J, “Stem cells for Parkinson disease and ALS: replacement or protection?,” Nat. Med. 10:224-225 (2004).
Tabrizi S & Schapira A, “Mitochondrial abnormalities in neurodegenerative diseases,” in Mitochondrial Disorders in Neurology vol. 2, 143-174 (Schapira A & DiMauro S. ed. 2002).
Calkins Marcus J.
Johnson Jeffrey A.
Dutt Aditi
Quarles & Brady LLP
Stucker Jeffrey
Wisconsin Alumni Research Foundation
LandOfFree
Method of diminishing the symptoms of neurodegenerative disease does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Method of diminishing the symptoms of neurodegenerative disease, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of diminishing the symptoms of neurodegenerative disease will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-4109822