Method of diminishing glucose levels resulting from endogenous g

Details Method of diminishing glucose levels resulting from endogenous g Method of diminishing glucose levels resulting from endogenous g

1981-12-22

1984-02-07

Phillips, Delbert R.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Reduced antigenicity, reduced ability to bind complement, or...

A61K 3702

Patent

active

044303262

ABSTRACT:
Effects of endogenous glucagon in mammals are diminished by administration of compositions including certain semi-synthetic analogs of glucagon. Preferred analogs include [N.sup..alpha. -TNB, HArg.sup.12 ]glucagon and [dHis.sup.1 ][N.sup..alpha. -TNB, HArg.sup.12 ]glucagon, parenterally administered at doses of from about 0.05 to about 50 mg of analog per kg of body weight.

REFERENCES:
patent: 3715348 (1973-02-01), Smith
patent: 4206199 (1980-01-01), Fujino et al.
patent: 4221777 (1980-09-01), Nishino
Bergman et al., The Journal of Biological Chemistry, 255, pp. 11725-11731 (1980).
Lin et al., Biochemistry, 14, pp. 1559-1563 (1975).
Epand et al., Biochemica et Biophysica Acta, 393, pp. 236-246 (1975).
Wright et al., The Journal of Biological Chemistry, 253, pp. 6338-6340 (1978).

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