Method of differentiation induction to osteoblasts

Details Method of differentiation induction to osteoblasts Method of differentiation induction to osteoblasts

2007-08-20

2010-11-09

Falk, Anne-Marie (Department: 1632)

Chemistry: molecular biology and microbiology

Animal cell, per se ; composition thereof; process of...

Method of regulating cell metabolism or physiology

C435S375000

Reexamination Certificate

active

07829335

ABSTRACT:
The invention offers a technique that selectively differentiation-induces mesenchymal stem cells, which can differentiate to cells that constitute various tissues and organs, to osteoblasts. In addition, the invention offers a technique that differentiation-induces mesenchymal stem cells to osteoblasts with a simple operation that needs only short time and that is noninvasive. The inventors have found that the switch for the differentiation induction to osteoblasts is turned on by translocating biological clock-relevant factors existing in mesenchymal stem cells from the cells' cytoplasm to the cells' nucleus. The inventors have also found that the switch can be turned on by irradiating the cells for a short time with a lightwave having a specific wavelength that is noninvasive.

REFERENCES:
patent: 2004-129549 (2004-04-01), None
patent: 2005-124460 (2005-05-01), None
patent: 2005-247740 (2005-09-01), None
Abromavitch-Gottlib et al. “Low level laser irradiation stimulates osteogenic phenotype of mesenchymal stem cells seeded on three-dimensional biomatrix,”Lasers in Medical Science, vol. 20, pp. 138-146, 2005.
Dörtbudak et al. “Biostimulation of bone marrow cells with a diode soft laser,”Clinical Oral Implants Research, vol. 11, pp. 540-545, 2000.
Yamamoto et al. “Stimulation of MCM3 Gene Expression in Osteoblast by Low Level Laser Irradiation,”Lasers in Medical Science, vol. 16, pp. 213-217, 2001.
Stein et al. “Low-Level Irradiation Promotes Proliferation and Differentiation of Human Osteobalsts in Vitro,”Photomedicine and Laser Surgery, vol. 23, No. 2, pp. 161-166, 2005.
Fu et al. “The circadian modulation of leptin-controlled bone formation,”Progress in Brain Research, vol. 153, pp. 177-188, 2006.
Kushibiki et al. “A blue-violet laser irradiation stimulates bone nodule formation of mesenchymal stromal cells by the control of the circadian clock protein,”Proc. of SPIE, vol. 6435, pp. 64351B-1-64351B-5, 2007.
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English language Abstract of JP 2005-124460.
English language Abstract of JP 2004-129549.
English language Abstract of JP 2005-247740.
Jaiswal et al., “Osteogenic Differentiation of Purified, Culture-Expanded Human Mesenchymal Stem Cells In Vitro”Journal of Cellular Biochemistry64:295-312 (1997).

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