Method of diagnosis of amyloidosis

Details Method of diagnosis of amyloidosis Method of diagnosis of amyloidosis

1990-10-19

1992-03-31

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Radionuclide or intended radionuclide containing; adjuvant...

Molecular bilayer structure

A61K 4900

Patent

active

051006456

ABSTRACT:
In accordance with the present invention, there is now provided a method for the diagnosis of amyloidosis, which comprises subjecting a protein sample such as serum, cerebrospinal fluid or brain tissues containing amyloid deposits obtained from a patient suspected of suffering from an amyloidosis related disease to measurement of the amount of ubiquitin in said sample, and comparing the resulting amount with the amount of ubiquitin in a normal healthy patient. In a second aspect of the present invention, there is provided a method for the diagnosis of Alzheimer's disease, which comprises subjecting a protein sample obtained from the brain extract or cerebrospinal fluid of a patient suspected of suffering from Alzheimer's disease to measurement of the amount of ubiquitin, and comparing the resulting amount with the amount of ubiquitin in a normal healthy patient.

REFERENCES:
Saran, B. et al., Age 12(4):148 "Identification of Ubiquitin in the CSF of oung, Old, and AD Patients", Oct. 4-7, 1989.
Alizadeh-Khiavi, K. et al., Acta Neuropathol. (1991) 81: 280-286.
Chronopoulos, S. et al., J Pathol. (1991) 163: 199-203.
Chronopoulos, S. et al., J Pathol. 1991 "Ubiquitin: It's Potential Significance in Murine AA Amyloidogenesis".
Mann, D. et al., J Neurol. Neurosurg. Psychiatr. (1984) 47: 201-203.
Price, D. L. et al., Neuropep. Neurol. Psych. Disease (1986) Raven Press, N.Y. pp 209-213.
Katzman, R. et al., Neuropep Neurol Psych Disease (1986) Raven Press, N.Y. pp 279-286.
Suzuki, K. et al., J Neuropathol Exp Neurol (1965) 24: 211-224.
Jenkins, H. G. et al., J Neurochem 51(5): 1641-1645 (1988).

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