Method of diagnosis of amyloidoses

Details Method of diagnosis of amyloidoses Method of diagnosis of amyloidoses

1991-10-15

1993-12-14

Nucker, Christine M.

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

435 792, 435 793, 435 794, 435 795, 530380, 5303879, 5303882, G01N 3353

Patent

active

052701654

ABSTRACT:
A method of diagnosing a disease with cerebrovascular deposition of amyloid, including Alzheimer's disease, hereditary cerebral hemorrhage with amyloidosis-Dutch type and other amyloidoses, in a mammal is disclosed in which a sample of cerebrospinal fluid is obtained, the level of immunoreactivity toward a monoclonal antibody raised against native PN-2/.beta.APP or other amyloid precursor protein in the sample is measured, and this measured level is compared to the level of immunoreactivity toward this antibody in a sample from

REFERENCES:
patent: 4837164 (1989-06-01), Glick
Isolation & Characterization of Amyloid P Component--Cerebral Amyoidosis Coria et al; Lab Investn 58, #4, pp. 454-458, 1988.
Van Nostrand, W. E., and Cunningham, D. D., J. Biol. Chem., 262:8508-8514 (1987).
Baker, J. B. et al., Cell, 21:37-45 (1980).
Wagner, S. L., et al. Biochemistry, 27:2173-2176 (1988).
Bradford, M. M., Anal. Biochem., 72:248-254 (1976).
Laemmli, Nature, 227:680-685 (1970).
Potempa, et al., Science, 241:699-700 (1988).
Homsen et al., Anal. Biochem. 46:489-501 (1972).
Rucinski et al., Blood, 53:47-62 (1979).
Wroblewski and Ladue, Proc. Soc. Exper. Biol. Med., 90:210-213 (1955).
Schmaier, et al., J. Clin. Invest., 75:242-250 (1985).
Laurell, Anal. Biochem., 15:45-52 (1966).
de Duve et al, Biochem J., 60:604-617 (1955).
Weissbach et al., J. Biol. Chem., 230:865-871 (1955).
Weidemann et al., Cell, 57:115-126 (1989).
Joachim et al., Nature, 341:226.sub.]230 (1989).
Palmert et al., Science, 241:1080-1084 (1988).
Kang et al., Nature, 325:733-736 (1987).
Goldgaber et al., Science, 235:877-884 (1987).
Ponte et al., Nature, 331:525-532 (1988).
Dyrks et al., The Embo Journal, 7:949-957 (1988).
Shivers et al., The Embo Journal, 7:1365-1370 (1988).
Tate-Ostroff et al., Proc. Natl. Acad. Sci. USA, 86:745-749 (1989).
Hooper, C., J. NIH Res., 1:88-93 (1989).
Carrell, R. W., Nature, 331:478-479 (1988).
Kitaguchi et al., Determination of Amyloid B Protein Precursors . . . , Bioch. Biophys. Res. Comm., 166:1453-1459 (1990).
Ghiso et al., Alzheimer's Disease Amyloid Presucsor Protein is Present in Senile Plaques and Cerebrospinal Fluid, Bioch. Biophys. Res. Comm., 163:430-437 (1989).
Weidemann et al., Identification, Biogenesis, and Localization of Precursors of Alzheimer's Disease A4 Amyloid Protein, Cell, 57:115-126 (1989).
Marotta, C.A., et al. Proc. Natl. Acad. Sci. USA, 86:337-341 (1989).
Grubb et al., "Abnormal Metabolism of y-Trace Alkaline Microprotein" Medical Intelligence, 311:1547-1549 (1984).
Nature--vol. 341 Oct. 12, 1989 "Protease nexin-II, a potent anti-chymotrypsin, shows identity to amyloid B-protein precursor".
Van Nostrand et al, J. Biol. Chem., vol. 265, No. 17 pp. 9591-9594 (1990).
Prior et al., Neuroscience Letters, 124 (1991) 69-73.
Henriksson, et al., Journal of Neurochemistry, 1991 1037-1042.
Palmert, et al., Neurology 40 Jul. 1990 1028-1034.
Smith, et al, Science, vol. 248 1126-1128.
Van Nostrand, et al., Science, vol. 248, May 11, 1990 745-748.

Affiliated with

Also associated with

Rating

Method of diagnosis of amyloidoses does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Method of diagnosis of amyloidoses, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Method of diagnosis of amyloidoses will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1704312