Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving antigen-antibody binding – specific binding protein...
Patent
1987-07-28
1990-08-14
Warden, Robert J.
Chemistry: molecular biology and microbiology
Measuring or testing process involving enzymes or...
Involving antigen-antibody binding, specific binding protein...
435 28, 436518, 436528, 436533, 436548, 436811, 436813, 530327, 530328, 530329, 530812, G01N 3353, G01N 33543, C07K 706, C07K 1700
Patent
active
049487230
ABSTRACT:
Pancreatic disease can be diagnosed by assaying a patient's body fluid, e.g. serum or urine, for the activation peptides of pancreatic zymogens specifically cleaved by proteolysis during activation, (PAP) e.g. peptides including the sequence D.sub.4 K having the lysine as the carboxy terminus. When PAP is assayed for, the test provides a means for distinguishing necrotising acute pancreatitis from oedematous acute pancreatitis, provides for diagnosis of chronic pancreatitis in exacerbation, and permits monitoring of the severity progress of the disease. Also described are antibodies having specificity for the pancreatic activation peptides, as well as such peptides and antibodies which are labelled with revealing agents and/or immobilized on solid supports, and their use in diagnostic test kits.
REFERENCES:
patent: 4503143 (1985-03-01), Gerber et al.
Hermon-Taylor et al., Clinica Chimica Acta, vol. 109, 1981, pp. 203-209.
Terry et al., Clinica Chimica Acta, vol. 150, 1985, pp. 151-163.
Grataroli et al., Biochimie, vol. 63, 1981, pp. 677-684.
Eskola et al., Clin. Chem., vol. 29/10, 1983, pp. 1777-1780.
Sternby et al., Biochimica et Biophysica Acta, vol. 789, 1984, pp. 164-169.
Neralainen et al., Clin. Chem., vol. 31/7, 1985, pp. 1116-1120.
Geokas et al., The Journal of Biological Chemistry, vol. 252, No. 1, 1977, pp. 61-67.
Hermon-Taylor et al., Scand. J. Gastroenterol [Supp:] 1985, vol. 117, pp. 39-46.
Guy et al., Biochemistry, vol. 17, No. 9, 1978, pp. 1169-1675.
Sternby et al., Biochimica et Biophysica Acta, vol. 786, 1984, pp. 109-112.
Grataroli et al., Eur. J. Biochem., vol. 122, 1982, pp. 111-117.
Largman et al., Biochimica et Biophysica Acta, vol. 623, 1980, pp. 208-212.
Davis et al., (1955), J. Bio. Chem., 212:515-529.
Eskola et al., (1988), Clin. Chem., 34:1052-1054.
Gudgeon et al., (1988), Pancreas, 3:598.
Gudgeon et al., Pacreas (1988) 3:599.
Hurley et al., (1988), J. Immunological Methods, 111:195-203.
Msoero et al., (1982), Dig. Dis. Sci., 27:1089-1094.
Rinderknecht, 1988), Int. J. Pancreatology, 3:105-112.
Steinberg et al., Dig. Dis. Sci., (1984), 29:988-993.
Walsh, (1970) Methods in Enzymology 19:41-62.
Grant et al., (1979), Biochem. Piophys. Acta., 567: 207-215.
Magee et al., (1981), Biochem. J. 197:239-244.
Grant et al., (1983), Gut 24 (1):16-19.
Talbot et al., (1984) Digestive Diseases and Sciences 29(11):1009-1014.
Grant et al., (1984) Clinica Chmica Acta 142:39-45.
Cliffe et al., in "Proceedings of the 8th American Peptide Symposium", 1983, edited by Kruby and Rich (Pierce Chemical Company, Ill.), pp. 611-614.
Cliffe et al., (1985), Int. J. Peptide Protein Res. 25:663-672.
Austen Brian M.
Hermon-Taylor John
Bioscience International, Inc.
Hoffer Florina B.
Warden Robert J.
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