Drug – bio-affecting and body treating compositions – Radionuclide or intended radionuclide containing; adjuvant... – In an organic compound
Patent
1995-08-24
2000-12-26
Dees, Jose G.
Drug, bio-affecting and body treating compositions
Radionuclide or intended radionuclide containing; adjuvant...
In an organic compound
424 121, 424 185, A61K 5104, A61K 5112
Patent
active
061654418
ABSTRACT:
A method of therapeutical treatment of tumors, by photodynamic therapy comprising administering to a subject in need of said treatment an effective amount of a tumor-localizing photosensitizer consisting of a metal phthalocyanine, together with a minor amount of a tracer consisting of said metal phthalocyanine labelled with a radioactive isotope and non-invasively monitoring the concentration of said tracer in the target tumoral tissue and in the peritumoral tissue, thereby to identify the appropriate post-administration interval for performing the photodynamic therapy.
REFERENCES:
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Spectroscopic Studies on Zn(II)-Phthalocyanine on Homogeneous and Microheterogeneous System--G Valduga, E. Reddi and G. Jori. Journal of Inorganic Biochemistry, vol. 29, No. 1, pp. 59-65, 1987.
Iodine-131 Labeled Zn(II)-Phthalocyanine: A Potential Therapeutic Agent for Solid Tumours--R. Franceschini et al., European Journal of Nuclear Medicine, vol. 21, No. 8, p. 877. Aug. 21-24, 1994. [Abstract No. 611].
.sup.131 I-Zn(II)-Phthalocyanine: A Potential Radiotracer for Solid Tumours. Franceschini, R. et al., Symposium on Tumour Targeting with Radio Labelled Hormones and Antibodies. Dec. 9-10, 1994. Nuremberg, Germany.
Preparation of .sup.131 I-Label-Zn(II)-Phthalocyanine--R. Franceschini et.al. Appl. Radiol. Isot., Vo. 45, No. 3, pp. 385-403, 1994.
Lenaerts et al., "Nanocapsules with a reduced liver uptake: Targeting of Phthalocyanines to EMT-6 Mouse Mammary Tumour in Vivo", Eur. J. Pharm. Biopharm, 41(1) 1995, pp. 38-43.
Rousseau et al., "Biodistribution and Tumor Uptake of [Ga-67] Chlorogallium-tetraoctadecyloxy Phthalocyanine and its sulfonation Products in Tumor Bearing C-3H Mice," Nucl. Med. Biol., vol. 18, No. 7, pp. 777-782, 1991.
Valduga et al., "Spectroscopic Studies on Zn(II) Phthalocyanine in Homogeneous and Microheterogeneous Systems", Journal of Inorganic Biochemistry, 29, pp. 59-65, 1987.
Scasnar et al., "Biological Activities of Phthalocyanines-XV." Nucl. Med. Biol. vol. 20, No. 3, pp. 257-263, 1993.
Bocchiotti Giovanni
Franceschini Rodolfo
Iori Giulio
Polo Laura
Dees Jos,e G.
Hartley Michael G.
Kelley Margaret B.
Nycomed Amersham Sorin SRL
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