Method of diagnosis and kit of parts therefor

Details Method of diagnosis and kit of parts therefor Method of diagnosis and kit of parts therefor

2002-07-18

2009-08-18

Szperka, Michael (Department: 1644)

Chemistry: molecular biology and microbiology

Measuring or testing process involving enzymes or...

Involving antigen-antibody binding, specific binding protein...

C435S007920

Reexamination Certificate

active

07575871

ABSTRACT:
A method for diagnosing coeliac disease in a patient comprising (a) providing an antibody sample from the patient to be tested, (b) contacting said antibody sample with cross-linked extracellular matrix (ECM) material immobilized on a surface and (c) detecting binding of antibodies present in the sample to the ECM-coated surface, wherein the binding of antibodies present in the sample to the ECM-coated surface being indicative of a positive diagnosis. Preferably, step (c) comprises an ELISA. The invention further provides a kit of parts for use in diagnosing coeliac disease in a patient.

REFERENCES:
patent: 5654168 (1997-08-01), Bujard et al.
patent: 6319726 (2001-11-01), Schuppan et al.
patent: WO 98/03872 (1998-01-01), None
patent: WO 98/15836 (1998-04-01), None
patent: WO 02/086509 (2002-10-01), None
Marttinen et al., 1993, Pediatric Research, vol. 34: 420-423.
Aeschlimann et al., 2000, Conn. Tissue Res. vol. 41: 1-27.
Korponay-Szabo et al., 2003, Gut, vol. 52: 199-204.
Valeski et al., 1990, Int. Arch. Allergy, vol. 93: 1-7.
Chao et al., 1996, Cytometry, vol. 23: 48-53.
Dorland's Illustrated Medical Dicitonary, 2004, pp. 1-2.
Begos et al., “Metachronous Small-Bowel Adenocarcinoma in Celiac Sprue”,J Clin. Gastroenterol, 20(3):233-236 (1995).
Clemente et al., “Immune Reaction Against the Cytoskeleton in Coeliac Disease”, XP009011811.
Dieterich et al., “Identification of Tissue Transglutaminase as the Autoantigen of Celiac Disease”,Nature Medicine, 3(7):797-801 (1997).
Dieterich et al., “Characterization of the Autoantigens in Coeliac Disease”. XP-002243230.
Gentile et al., “Isolation and Characterization of cDNA Clones to Mouse Macrophage and Human Endothelial Cell Tissue Transglutaminases”,The Journal of Biological Chemistry, 266(1):478-483 (1991).
Greenberg et al., “Transglutaminases: Multifunctional Cross-Linking Enzymes That Stabilize Tissues”,The FASEB Journal, 5:3071-3077 (1991).
Logan et al., “Mortality in Celiac Disease”,Gastroenterology, 97:265-271 (1989).
Mäki, “The Humoral Immune System in Coeliac Disease”,Bailliére's Clinical Gastroenterology, 9(2): 231-249 (1995).
Sblatterto et al., “Human Recombinate Tissue Transglutaminase ELISA: An Innovative Diagnostic Assay for Celiac Disease”,The American Journal of Gastroenterology, 95(5):1253-1257 (2000).
Sollid, “Molecular Basis of Celiac Disease”,Annu. Rev. Immunol., 18:53-81 (2000).
Verderio et al., “Regulated Expression of Tissue Transglutaminase in Swiss 3T3 Fibroblasts: Effects on the Processing of Fibronectin, Cell Attachment, and Cell Death”,Experimental Cell Research, 239:119-138 (1998).
Barsigian, C. et al. (Nov. 25, 1991). “Tissue (Type II) Transglutaminase Covalently Incorporates Itself, Fibrinogen, or Fibronectin into High Molecular Weight Complexes on the Extracellular Surface of Isolated Hepatocytes,”J. Biol. Chem.266(33):22501-22509.
Gaudry, C.A. et al. (Oct. 22, 1999). “Cell Surface Localization of Tissue Transglutaminase Is Dependent on a Fibronectin-binding Site in Its N-terminal β-Sandwich Domain,”J. Biol. Chem.274(43):30707-30714.
Ghedira, I. et al. (2001). “Anticorps Anti-Endomysium, Anti-Réticuline at Anti-Giladine, Intérêt Dans le Diagnostic de la Maladie Coeliaque Chez L'Enfant,”Pathol. Biol.49:47-52. (English-language machine translation, six pages.).
Kojima, S. et al. (Apr. 1, 1993). “Requirement for Transglutaminase in the Activation of Latent Transforming Growth Factor-β in Bovine Endothelial Cells,”J. Cell Biol.121(2):439-448.
Nunes, I. et al.(Mar. 10. 1997). “Latent Transforming Growth Factor-β Binding Protein Domains Involved in Activation and Transglutaminase-dependent Cross-Linking of Latent Transforming Growth Factor-β,”J. Cell Biol.136(5):1151-1163.

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